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Upper respiratory virus detection without parent-reported illness in children is virus-specific

BACKGROUND: Viral upper respiratory tract infection (vURI) may or may not present with a cold/flu-like illness (CFLI). OBJECTIVES: For common upper respiratory viruses that cause vURIs, to determine the relative frequencies of virus detection by PCR in subjects with and without CFLIs. STUDY DESIGN:...

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Autores principales: Alper, Cuneyt M., Doyle, William J., Winther, Birgit, Owen Hendley, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108336/
https://www.ncbi.nlm.nih.gov/pubmed/18538629
http://dx.doi.org/10.1016/j.jcv.2008.04.008
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author Alper, Cuneyt M.
Doyle, William J.
Winther, Birgit
Owen Hendley, J.
author_facet Alper, Cuneyt M.
Doyle, William J.
Winther, Birgit
Owen Hendley, J.
author_sort Alper, Cuneyt M.
collection PubMed
description BACKGROUND: Viral upper respiratory tract infection (vURI) may or may not present with a cold/flu-like illness (CFLI). OBJECTIVES: For common upper respiratory viruses that cause vURIs, to determine the relative frequencies of virus detection by PCR in subjects with and without CFLIs. STUDY DESIGN: Prospective follow-up of 170 children aged 1–8.6 years through the CFLI season by daily parental diary for CFLI episodes and nasal secretion sampling using PCR assays for adenovirus, coronavirus (types 229E and OC43), influenza virus (types A and B), parainfluenza (types 1–3) virus, rhinovirus, and respiratory syncytial virus (RSV). RESULTS: Virus was detected in 415 of 956 independent assays: 425 CFLI episodes and 531 non-CFLI periods were sampled; samples from 270 (64%) CFLI episodes and 145 (27%) non-CFLI periods contained virus detected by PCR. Rhinovirus was most frequently detected at 64%, followed by mixed viruses at 12%, RSV at 7%, and the other viruses at 3–5% of all detections. About 85% of RSV, influenza A and adenovirus detections were associated with a CFLI, whereas less than 62% of other virus detections were associated with CFLI. CONCLUSIONS: The frequency of PCR virus detection without CFLI was different among viruses. This introduces virus-specific biases to estimating the frequencies of specific complications attributable to a vURI when ascertained by CFLI identification.
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spelling pubmed-71083362020-03-31 Upper respiratory virus detection without parent-reported illness in children is virus-specific Alper, Cuneyt M. Doyle, William J. Winther, Birgit Owen Hendley, J. J Clin Virol Article BACKGROUND: Viral upper respiratory tract infection (vURI) may or may not present with a cold/flu-like illness (CFLI). OBJECTIVES: For common upper respiratory viruses that cause vURIs, to determine the relative frequencies of virus detection by PCR in subjects with and without CFLIs. STUDY DESIGN: Prospective follow-up of 170 children aged 1–8.6 years through the CFLI season by daily parental diary for CFLI episodes and nasal secretion sampling using PCR assays for adenovirus, coronavirus (types 229E and OC43), influenza virus (types A and B), parainfluenza (types 1–3) virus, rhinovirus, and respiratory syncytial virus (RSV). RESULTS: Virus was detected in 415 of 956 independent assays: 425 CFLI episodes and 531 non-CFLI periods were sampled; samples from 270 (64%) CFLI episodes and 145 (27%) non-CFLI periods contained virus detected by PCR. Rhinovirus was most frequently detected at 64%, followed by mixed viruses at 12%, RSV at 7%, and the other viruses at 3–5% of all detections. About 85% of RSV, influenza A and adenovirus detections were associated with a CFLI, whereas less than 62% of other virus detections were associated with CFLI. CONCLUSIONS: The frequency of PCR virus detection without CFLI was different among viruses. This introduces virus-specific biases to estimating the frequencies of specific complications attributable to a vURI when ascertained by CFLI identification. Elsevier B.V. 2008-09 2008-06-05 /pmc/articles/PMC7108336/ /pubmed/18538629 http://dx.doi.org/10.1016/j.jcv.2008.04.008 Text en Copyright © 2008 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Alper, Cuneyt M.
Doyle, William J.
Winther, Birgit
Owen Hendley, J.
Upper respiratory virus detection without parent-reported illness in children is virus-specific
title Upper respiratory virus detection without parent-reported illness in children is virus-specific
title_full Upper respiratory virus detection without parent-reported illness in children is virus-specific
title_fullStr Upper respiratory virus detection without parent-reported illness in children is virus-specific
title_full_unstemmed Upper respiratory virus detection without parent-reported illness in children is virus-specific
title_short Upper respiratory virus detection without parent-reported illness in children is virus-specific
title_sort upper respiratory virus detection without parent-reported illness in children is virus-specific
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108336/
https://www.ncbi.nlm.nih.gov/pubmed/18538629
http://dx.doi.org/10.1016/j.jcv.2008.04.008
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