Cargando…
Upper respiratory virus detection without parent-reported illness in children is virus-specific
BACKGROUND: Viral upper respiratory tract infection (vURI) may or may not present with a cold/flu-like illness (CFLI). OBJECTIVES: For common upper respiratory viruses that cause vURIs, to determine the relative frequencies of virus detection by PCR in subjects with and without CFLIs. STUDY DESIGN:...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier B.V.
2008
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108336/ https://www.ncbi.nlm.nih.gov/pubmed/18538629 http://dx.doi.org/10.1016/j.jcv.2008.04.008 |
_version_ | 1783512790541008896 |
---|---|
author | Alper, Cuneyt M. Doyle, William J. Winther, Birgit Owen Hendley, J. |
author_facet | Alper, Cuneyt M. Doyle, William J. Winther, Birgit Owen Hendley, J. |
author_sort | Alper, Cuneyt M. |
collection | PubMed |
description | BACKGROUND: Viral upper respiratory tract infection (vURI) may or may not present with a cold/flu-like illness (CFLI). OBJECTIVES: For common upper respiratory viruses that cause vURIs, to determine the relative frequencies of virus detection by PCR in subjects with and without CFLIs. STUDY DESIGN: Prospective follow-up of 170 children aged 1–8.6 years through the CFLI season by daily parental diary for CFLI episodes and nasal secretion sampling using PCR assays for adenovirus, coronavirus (types 229E and OC43), influenza virus (types A and B), parainfluenza (types 1–3) virus, rhinovirus, and respiratory syncytial virus (RSV). RESULTS: Virus was detected in 415 of 956 independent assays: 425 CFLI episodes and 531 non-CFLI periods were sampled; samples from 270 (64%) CFLI episodes and 145 (27%) non-CFLI periods contained virus detected by PCR. Rhinovirus was most frequently detected at 64%, followed by mixed viruses at 12%, RSV at 7%, and the other viruses at 3–5% of all detections. About 85% of RSV, influenza A and adenovirus detections were associated with a CFLI, whereas less than 62% of other virus detections were associated with CFLI. CONCLUSIONS: The frequency of PCR virus detection without CFLI was different among viruses. This introduces virus-specific biases to estimating the frequencies of specific complications attributable to a vURI when ascertained by CFLI identification. |
format | Online Article Text |
id | pubmed-7108336 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71083362020-03-31 Upper respiratory virus detection without parent-reported illness in children is virus-specific Alper, Cuneyt M. Doyle, William J. Winther, Birgit Owen Hendley, J. J Clin Virol Article BACKGROUND: Viral upper respiratory tract infection (vURI) may or may not present with a cold/flu-like illness (CFLI). OBJECTIVES: For common upper respiratory viruses that cause vURIs, to determine the relative frequencies of virus detection by PCR in subjects with and without CFLIs. STUDY DESIGN: Prospective follow-up of 170 children aged 1–8.6 years through the CFLI season by daily parental diary for CFLI episodes and nasal secretion sampling using PCR assays for adenovirus, coronavirus (types 229E and OC43), influenza virus (types A and B), parainfluenza (types 1–3) virus, rhinovirus, and respiratory syncytial virus (RSV). RESULTS: Virus was detected in 415 of 956 independent assays: 425 CFLI episodes and 531 non-CFLI periods were sampled; samples from 270 (64%) CFLI episodes and 145 (27%) non-CFLI periods contained virus detected by PCR. Rhinovirus was most frequently detected at 64%, followed by mixed viruses at 12%, RSV at 7%, and the other viruses at 3–5% of all detections. About 85% of RSV, influenza A and adenovirus detections were associated with a CFLI, whereas less than 62% of other virus detections were associated with CFLI. CONCLUSIONS: The frequency of PCR virus detection without CFLI was different among viruses. This introduces virus-specific biases to estimating the frequencies of specific complications attributable to a vURI when ascertained by CFLI identification. Elsevier B.V. 2008-09 2008-06-05 /pmc/articles/PMC7108336/ /pubmed/18538629 http://dx.doi.org/10.1016/j.jcv.2008.04.008 Text en Copyright © 2008 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Alper, Cuneyt M. Doyle, William J. Winther, Birgit Owen Hendley, J. Upper respiratory virus detection without parent-reported illness in children is virus-specific |
title | Upper respiratory virus detection without parent-reported illness in children is virus-specific |
title_full | Upper respiratory virus detection without parent-reported illness in children is virus-specific |
title_fullStr | Upper respiratory virus detection without parent-reported illness in children is virus-specific |
title_full_unstemmed | Upper respiratory virus detection without parent-reported illness in children is virus-specific |
title_short | Upper respiratory virus detection without parent-reported illness in children is virus-specific |
title_sort | upper respiratory virus detection without parent-reported illness in children is virus-specific |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108336/ https://www.ncbi.nlm.nih.gov/pubmed/18538629 http://dx.doi.org/10.1016/j.jcv.2008.04.008 |
work_keys_str_mv | AT alpercuneytm upperrespiratoryvirusdetectionwithoutparentreportedillnessinchildrenisvirusspecific AT doylewilliamj upperrespiratoryvirusdetectionwithoutparentreportedillnessinchildrenisvirusspecific AT wintherbirgit upperrespiratoryvirusdetectionwithoutparentreportedillnessinchildrenisvirusspecific AT owenhendleyj upperrespiratoryvirusdetectionwithoutparentreportedillnessinchildrenisvirusspecific |