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Age-related pattern of KI and WU polyomavirus infection

BACKGROUND: The role of two recently identified polyomaviruses, KI and WU, in the causation of respiratory disease has not been established. OBJECTIVES: To determine the prevalence of KI and WU viruses (KIV and WUV) in 371 respiratory samples and evaluate their contribution to respiratory disease. S...

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Autores principales: Abedi Kiasari, B., Vallely, P.J., Corless, C.E., Al-Hammadi, M., Klapper, P.E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108349/
https://www.ncbi.nlm.nih.gov/pubmed/18573691
http://dx.doi.org/10.1016/j.jcv.2008.05.003
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author Abedi Kiasari, B.
Vallely, P.J.
Corless, C.E.
Al-Hammadi, M.
Klapper, P.E.
author_facet Abedi Kiasari, B.
Vallely, P.J.
Corless, C.E.
Al-Hammadi, M.
Klapper, P.E.
author_sort Abedi Kiasari, B.
collection PubMed
description BACKGROUND: The role of two recently identified polyomaviruses, KI and WU, in the causation of respiratory disease has not been established. OBJECTIVES: To determine the prevalence of KI and WU viruses (KIV and WUV) in 371 respiratory samples and evaluate their contribution to respiratory disease. STUDY DESIGN: Specimens were screened for KIV and WUV using single, multiplex or real time PCR; co-infection with other respiratory viruses was evaluated. RESULTS: Of the 371 samples analysed, 10 (2.70%) were positive for KIV and 4 (1.08%) were positive for WUV yielding an overall case prevalence of KIV and WUV infection of 3.77%. KIV and WUV were identified in patients aged <15 years (11 patients) with upper or lower respiratory tract infection and >45 years (3 patients) with upper respiratory tract infection. Co-infections were found in 5 (50%) and 3 (75%) of the KIV and WUV positive samples, respectively. CONCLUSIONS: This study supports previous conclusions that KIV and WUV detection in the respiratory tract may be coincidental and reflect reactivation of latent or persistent infection with these viruses. The age distribution of KIV and WUV infection in this study mirrors that found for the other human polyomaviruses, BK and JC.
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spelling pubmed-71083492020-03-31 Age-related pattern of KI and WU polyomavirus infection Abedi Kiasari, B. Vallely, P.J. Corless, C.E. Al-Hammadi, M. Klapper, P.E. J Clin Virol Article BACKGROUND: The role of two recently identified polyomaviruses, KI and WU, in the causation of respiratory disease has not been established. OBJECTIVES: To determine the prevalence of KI and WU viruses (KIV and WUV) in 371 respiratory samples and evaluate their contribution to respiratory disease. STUDY DESIGN: Specimens were screened for KIV and WUV using single, multiplex or real time PCR; co-infection with other respiratory viruses was evaluated. RESULTS: Of the 371 samples analysed, 10 (2.70%) were positive for KIV and 4 (1.08%) were positive for WUV yielding an overall case prevalence of KIV and WUV infection of 3.77%. KIV and WUV were identified in patients aged <15 years (11 patients) with upper or lower respiratory tract infection and >45 years (3 patients) with upper respiratory tract infection. Co-infections were found in 5 (50%) and 3 (75%) of the KIV and WUV positive samples, respectively. CONCLUSIONS: This study supports previous conclusions that KIV and WUV detection in the respiratory tract may be coincidental and reflect reactivation of latent or persistent infection with these viruses. The age distribution of KIV and WUV infection in this study mirrors that found for the other human polyomaviruses, BK and JC. Elsevier B.V. 2008-09 2008-06-24 /pmc/articles/PMC7108349/ /pubmed/18573691 http://dx.doi.org/10.1016/j.jcv.2008.05.003 Text en Copyright © 2008 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Abedi Kiasari, B.
Vallely, P.J.
Corless, C.E.
Al-Hammadi, M.
Klapper, P.E.
Age-related pattern of KI and WU polyomavirus infection
title Age-related pattern of KI and WU polyomavirus infection
title_full Age-related pattern of KI and WU polyomavirus infection
title_fullStr Age-related pattern of KI and WU polyomavirus infection
title_full_unstemmed Age-related pattern of KI and WU polyomavirus infection
title_short Age-related pattern of KI and WU polyomavirus infection
title_sort age-related pattern of ki and wu polyomavirus infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108349/
https://www.ncbi.nlm.nih.gov/pubmed/18573691
http://dx.doi.org/10.1016/j.jcv.2008.05.003
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