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The use of genomics in microbial vaccine development
Vaccination is one of the most effective tools for the prevention of infectious diseases. The availability of complete genome sequences, together with the progression of high-throughput technologies such as functional and structural genomics, has led to a new paradigm in vaccine development. Pan-gen...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Published by Elsevier Ltd.
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108364/ https://www.ncbi.nlm.nih.gov/pubmed/19150507 http://dx.doi.org/10.1016/j.drudis.2008.12.007 |
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author | Bambini, Stefania Rappuoli, Rino |
author_facet | Bambini, Stefania Rappuoli, Rino |
author_sort | Bambini, Stefania |
collection | PubMed |
description | Vaccination is one of the most effective tools for the prevention of infectious diseases. The availability of complete genome sequences, together with the progression of high-throughput technologies such as functional and structural genomics, has led to a new paradigm in vaccine development. Pan-genomic reverse vaccinology, with the comparison of sequence data from multiple isolates of the same species of a pathogen, increases the opportunity of the identification of novel vaccine candidates. Overall, the conventional empiric approach to vaccine development is being replaced by vaccine design. The recent development of synthetic genomics may provide a further opportunity to design vaccines. |
format | Online Article Text |
id | pubmed-7108364 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Published by Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71083642020-03-31 The use of genomics in microbial vaccine development Bambini, Stefania Rappuoli, Rino Drug Discov Today Article Vaccination is one of the most effective tools for the prevention of infectious diseases. The availability of complete genome sequences, together with the progression of high-throughput technologies such as functional and structural genomics, has led to a new paradigm in vaccine development. Pan-genomic reverse vaccinology, with the comparison of sequence data from multiple isolates of the same species of a pathogen, increases the opportunity of the identification of novel vaccine candidates. Overall, the conventional empiric approach to vaccine development is being replaced by vaccine design. The recent development of synthetic genomics may provide a further opportunity to design vaccines. Published by Elsevier Ltd. 2009-03 2009-01-15 /pmc/articles/PMC7108364/ /pubmed/19150507 http://dx.doi.org/10.1016/j.drudis.2008.12.007 Text en Copyright © 2009 Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Bambini, Stefania Rappuoli, Rino The use of genomics in microbial vaccine development |
title | The use of genomics in microbial vaccine development |
title_full | The use of genomics in microbial vaccine development |
title_fullStr | The use of genomics in microbial vaccine development |
title_full_unstemmed | The use of genomics in microbial vaccine development |
title_short | The use of genomics in microbial vaccine development |
title_sort | use of genomics in microbial vaccine development |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108364/ https://www.ncbi.nlm.nih.gov/pubmed/19150507 http://dx.doi.org/10.1016/j.drudis.2008.12.007 |
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