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Human Papillomavirus and carcinogenesis: Novel mechanisms of cell communication involving extracellular vesicles

A small group of mucosal Human Papillomaviruses are the causative agents of cervical cancer and are also associated with other types of cancers. Certain cutaneous Human Papillomaviruses seem to have a role as co-factors in the UV-induced carcinogenesis of the skin. The main mechanism of the tumorige...

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Autores principales: Chiantore, Maria Vincenza, Mangino, Giorgio, Iuliano, Marco, Capriotti, Lorena, Di Bonito, Paola, Fiorucci, Gianna, Romeo, Giovanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108386/
https://www.ncbi.nlm.nih.gov/pubmed/31973992
http://dx.doi.org/10.1016/j.cytogfr.2019.12.009
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author Chiantore, Maria Vincenza
Mangino, Giorgio
Iuliano, Marco
Capriotti, Lorena
Di Bonito, Paola
Fiorucci, Gianna
Romeo, Giovanna
author_facet Chiantore, Maria Vincenza
Mangino, Giorgio
Iuliano, Marco
Capriotti, Lorena
Di Bonito, Paola
Fiorucci, Gianna
Romeo, Giovanna
author_sort Chiantore, Maria Vincenza
collection PubMed
description A small group of mucosal Human Papillomaviruses are the causative agents of cervical cancer and are also associated with other types of cancers. Certain cutaneous Human Papillomaviruses seem to have a role as co-factors in the UV-induced carcinogenesis of the skin. The main mechanism of the tumorigenesis induced by Human Papillomaviruses is linked to the transforming activity of the viral E6 and E7 oncoproteins. However, other mechanisms, such as the gene expression control by specific microRNAs expression and deregulation of immune inflammatory mediators, may be important in the process of transformation. In this context, the release of Extracellular Vesicles with a specific cargo (microRNAs involved in tumorigenesis, mRNAs of viral oncoproteins, cytokines, chemokines) appears to play a key role.
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spelling pubmed-71083862020-03-31 Human Papillomavirus and carcinogenesis: Novel mechanisms of cell communication involving extracellular vesicles Chiantore, Maria Vincenza Mangino, Giorgio Iuliano, Marco Capriotti, Lorena Di Bonito, Paola Fiorucci, Gianna Romeo, Giovanna Cytokine Growth Factor Rev Article A small group of mucosal Human Papillomaviruses are the causative agents of cervical cancer and are also associated with other types of cancers. Certain cutaneous Human Papillomaviruses seem to have a role as co-factors in the UV-induced carcinogenesis of the skin. The main mechanism of the tumorigenesis induced by Human Papillomaviruses is linked to the transforming activity of the viral E6 and E7 oncoproteins. However, other mechanisms, such as the gene expression control by specific microRNAs expression and deregulation of immune inflammatory mediators, may be important in the process of transformation. In this context, the release of Extracellular Vesicles with a specific cargo (microRNAs involved in tumorigenesis, mRNAs of viral oncoproteins, cytokines, chemokines) appears to play a key role. Elsevier Ltd. 2020-02 2020-01-18 /pmc/articles/PMC7108386/ /pubmed/31973992 http://dx.doi.org/10.1016/j.cytogfr.2019.12.009 Text en © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Chiantore, Maria Vincenza
Mangino, Giorgio
Iuliano, Marco
Capriotti, Lorena
Di Bonito, Paola
Fiorucci, Gianna
Romeo, Giovanna
Human Papillomavirus and carcinogenesis: Novel mechanisms of cell communication involving extracellular vesicles
title Human Papillomavirus and carcinogenesis: Novel mechanisms of cell communication involving extracellular vesicles
title_full Human Papillomavirus and carcinogenesis: Novel mechanisms of cell communication involving extracellular vesicles
title_fullStr Human Papillomavirus and carcinogenesis: Novel mechanisms of cell communication involving extracellular vesicles
title_full_unstemmed Human Papillomavirus and carcinogenesis: Novel mechanisms of cell communication involving extracellular vesicles
title_short Human Papillomavirus and carcinogenesis: Novel mechanisms of cell communication involving extracellular vesicles
title_sort human papillomavirus and carcinogenesis: novel mechanisms of cell communication involving extracellular vesicles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108386/
https://www.ncbi.nlm.nih.gov/pubmed/31973992
http://dx.doi.org/10.1016/j.cytogfr.2019.12.009
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