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Regulatory interplay between deubiquitinating enzymes and cytokines
Deubiquitinating enzymes (DUBs) are cysteine protease proteins that reverse the ubiquitination by removing ubiquitins from the target protein. With over 100 DUBs identified and categorized into at least 7 families, many DUBs interact with one or more cytokines, influencing cellular processes, such a...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Published by Elsevier Ltd.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108389/ https://www.ncbi.nlm.nih.gov/pubmed/31208841 http://dx.doi.org/10.1016/j.cytogfr.2019.06.001 |
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author | Woo, Bean Baek, Kwang-Hyun |
author_facet | Woo, Bean Baek, Kwang-Hyun |
author_sort | Woo, Bean |
collection | PubMed |
description | Deubiquitinating enzymes (DUBs) are cysteine protease proteins that reverse the ubiquitination by removing ubiquitins from the target protein. With over 100 DUBs identified and categorized into at least 7 families, many DUBs interact with one or more cytokines, influencing cellular processes, such as antiviral responses, inflammatory responses, apoptosis, etc. While some DUBs influence cytokine pathway or production, some DUBs are cytokine-inducible. In this article, we summarize a list of DUBs, their interaction with cytokines, target proteins and mechanisms of action. |
format | Online Article Text |
id | pubmed-7108389 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Published by Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71083892020-03-31 Regulatory interplay between deubiquitinating enzymes and cytokines Woo, Bean Baek, Kwang-Hyun Cytokine Growth Factor Rev Article Deubiquitinating enzymes (DUBs) are cysteine protease proteins that reverse the ubiquitination by removing ubiquitins from the target protein. With over 100 DUBs identified and categorized into at least 7 families, many DUBs interact with one or more cytokines, influencing cellular processes, such as antiviral responses, inflammatory responses, apoptosis, etc. While some DUBs influence cytokine pathway or production, some DUBs are cytokine-inducible. In this article, we summarize a list of DUBs, their interaction with cytokines, target proteins and mechanisms of action. Published by Elsevier Ltd. 2019-08 2019-06-08 /pmc/articles/PMC7108389/ /pubmed/31208841 http://dx.doi.org/10.1016/j.cytogfr.2019.06.001 Text en © 2019 Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Woo, Bean Baek, Kwang-Hyun Regulatory interplay between deubiquitinating enzymes and cytokines |
title | Regulatory interplay between deubiquitinating enzymes and cytokines |
title_full | Regulatory interplay between deubiquitinating enzymes and cytokines |
title_fullStr | Regulatory interplay between deubiquitinating enzymes and cytokines |
title_full_unstemmed | Regulatory interplay between deubiquitinating enzymes and cytokines |
title_short | Regulatory interplay between deubiquitinating enzymes and cytokines |
title_sort | regulatory interplay between deubiquitinating enzymes and cytokines |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108389/ https://www.ncbi.nlm.nih.gov/pubmed/31208841 http://dx.doi.org/10.1016/j.cytogfr.2019.06.001 |
work_keys_str_mv | AT woobean regulatoryinterplaybetweendeubiquitinatingenzymesandcytokines AT baekkwanghyun regulatoryinterplaybetweendeubiquitinatingenzymesandcytokines |