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Microarrays in infection and immunity
Over the past decade, microarrays have revolutionized the scientific world as dramatically as the internet has changed everyday life. From the initial applications of DNA microarrays to uncover gene expression patterns that are diagnostic and prognostic of cancer, understanding the interplay between...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Ltd.
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108391/ https://www.ncbi.nlm.nih.gov/pubmed/17500025 http://dx.doi.org/10.1016/j.cbpa.2007.01.727 |
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author | Maynard, Jennifer A Myhre, Ryan Roy, Benjamin |
author_facet | Maynard, Jennifer A Myhre, Ryan Roy, Benjamin |
author_sort | Maynard, Jennifer A |
collection | PubMed |
description | Over the past decade, microarrays have revolutionized the scientific world as dramatically as the internet has changed everyday life. From the initial applications of DNA microarrays to uncover gene expression patterns that are diagnostic and prognostic of cancer, understanding the interplay between immune responses and disease has been a prime application of this technology. More recent efforts have moved beyond genetic analysis to functional analysis of the molecules involved, including identification of immunodominant antigens and peptides as well as the role of post-translational glycosylation. Here, we focus on recent applications of microarray technology in understanding the detailed chemical biology of immune responses to disease in an effort to guide development of vaccines and other protective therapies. |
format | Online Article Text |
id | pubmed-7108391 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71083912020-03-31 Microarrays in infection and immunity Maynard, Jennifer A Myhre, Ryan Roy, Benjamin Curr Opin Chem Biol Article Over the past decade, microarrays have revolutionized the scientific world as dramatically as the internet has changed everyday life. From the initial applications of DNA microarrays to uncover gene expression patterns that are diagnostic and prognostic of cancer, understanding the interplay between immune responses and disease has been a prime application of this technology. More recent efforts have moved beyond genetic analysis to functional analysis of the molecules involved, including identification of immunodominant antigens and peptides as well as the role of post-translational glycosylation. Here, we focus on recent applications of microarray technology in understanding the detailed chemical biology of immune responses to disease in an effort to guide development of vaccines and other protective therapies. Elsevier Ltd. 2007-06 2007-05-17 /pmc/articles/PMC7108391/ /pubmed/17500025 http://dx.doi.org/10.1016/j.cbpa.2007.01.727 Text en Copyright © 2006 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Maynard, Jennifer A Myhre, Ryan Roy, Benjamin Microarrays in infection and immunity |
title | Microarrays in infection and immunity |
title_full | Microarrays in infection and immunity |
title_fullStr | Microarrays in infection and immunity |
title_full_unstemmed | Microarrays in infection and immunity |
title_short | Microarrays in infection and immunity |
title_sort | microarrays in infection and immunity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108391/ https://www.ncbi.nlm.nih.gov/pubmed/17500025 http://dx.doi.org/10.1016/j.cbpa.2007.01.727 |
work_keys_str_mv | AT maynardjennifera microarraysininfectionandimmunity AT myhreryan microarraysininfectionandimmunity AT roybenjamin microarraysininfectionandimmunity |