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Airborne infectious disease and the suppression of pulmonary bioaerosols

The current understanding of airborne pathogen spread in relation to the new methods of suppressing exhaled bioaerosols using safe surface-active materials, such as isotonic saline, is reviewed here. We discuss the physics of bioaerosol generation in the lungs, what is currently known about the rela...

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Detalles Bibliográficos
Autores principales: Fiegel, Jennifer, Clarke, Robert, Edwards, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108402/
https://www.ncbi.nlm.nih.gov/pubmed/16478691
http://dx.doi.org/10.1016/S1359-6446(05)03687-1
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author Fiegel, Jennifer
Clarke, Robert
Edwards, David A.
author_facet Fiegel, Jennifer
Clarke, Robert
Edwards, David A.
author_sort Fiegel, Jennifer
collection PubMed
description The current understanding of airborne pathogen spread in relation to the new methods of suppressing exhaled bioaerosols using safe surface-active materials, such as isotonic saline, is reviewed here. We discuss the physics of bioaerosol generation in the lungs, what is currently known about the relationship between expired bioaerosols and airborne infectious disease and current methods of airborne infectious disease containment. We conclude by reviewing recent experiments that suggest the delivery of isotonic saline can significantly diminish exhaled aerosol – generated from airway lining fluid in the course of natural breathing. We also discuss these implications in relation to airborne infectious disease control.
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spelling pubmed-71084022020-03-31 Airborne infectious disease and the suppression of pulmonary bioaerosols Fiegel, Jennifer Clarke, Robert Edwards, David A. Drug Discov Today Review The current understanding of airborne pathogen spread in relation to the new methods of suppressing exhaled bioaerosols using safe surface-active materials, such as isotonic saline, is reviewed here. We discuss the physics of bioaerosol generation in the lungs, what is currently known about the relationship between expired bioaerosols and airborne infectious disease and current methods of airborne infectious disease containment. We conclude by reviewing recent experiments that suggest the delivery of isotonic saline can significantly diminish exhaled aerosol – generated from airway lining fluid in the course of natural breathing. We also discuss these implications in relation to airborne infectious disease control. Elsevier Ltd. 2006-01 2006-02-13 /pmc/articles/PMC7108402/ /pubmed/16478691 http://dx.doi.org/10.1016/S1359-6446(05)03687-1 Text en Copyright © 2006 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Fiegel, Jennifer
Clarke, Robert
Edwards, David A.
Airborne infectious disease and the suppression of pulmonary bioaerosols
title Airborne infectious disease and the suppression of pulmonary bioaerosols
title_full Airborne infectious disease and the suppression of pulmonary bioaerosols
title_fullStr Airborne infectious disease and the suppression of pulmonary bioaerosols
title_full_unstemmed Airborne infectious disease and the suppression of pulmonary bioaerosols
title_short Airborne infectious disease and the suppression of pulmonary bioaerosols
title_sort airborne infectious disease and the suppression of pulmonary bioaerosols
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108402/
https://www.ncbi.nlm.nih.gov/pubmed/16478691
http://dx.doi.org/10.1016/S1359-6446(05)03687-1
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