Viability of pathogenic dermatophytes during a 4-week treatment with 1% topical luliconazole for tinea pedis

The viability of pathogenic fungi in the scale was investigated during topical administration of 1% luliconazole (LLCZ). Thirteen tinea pedis patients found to be positive on KOH examination were assessed by mycological examinations and quantitative real-time polymerase chain reaction (PCR) targeted...

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Autores principales: Iwanaga, Tomoyuki, Ushigami, Tsuyoshi, Anzawa, Kazushi, Mochizuki, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108760/
https://www.ncbi.nlm.nih.gov/pubmed/31111903
http://dx.doi.org/10.1093/mmy/myz056
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author Iwanaga, Tomoyuki
Ushigami, Tsuyoshi
Anzawa, Kazushi
Mochizuki, Takashi
author_facet Iwanaga, Tomoyuki
Ushigami, Tsuyoshi
Anzawa, Kazushi
Mochizuki, Takashi
author_sort Iwanaga, Tomoyuki
collection PubMed
description The viability of pathogenic fungi in the scale was investigated during topical administration of 1% luliconazole (LLCZ). Thirteen tinea pedis patients found to be positive on KOH examination were assessed by mycological examinations and quantitative real-time polymerase chain reaction (PCR) targeted internal transcribed spacer (ITS) in ribosomal RNA gene at the initial visit and after 2 and 4 weeks of treatment. Assays showed that the average copy number of ITS DNA had significantly decreased to 22.9% at 2 weeks and 4.8% at 4 weeks compared with the initial visit. LLCZ topical treatment could defeat almost pathogenic dermatophytes in the scales within 4 weeks.
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spelling pubmed-71087602020-04-06 Viability of pathogenic dermatophytes during a 4-week treatment with 1% topical luliconazole for tinea pedis Iwanaga, Tomoyuki Ushigami, Tsuyoshi Anzawa, Kazushi Mochizuki, Takashi Med Mycol Brief Report The viability of pathogenic fungi in the scale was investigated during topical administration of 1% luliconazole (LLCZ). Thirteen tinea pedis patients found to be positive on KOH examination were assessed by mycological examinations and quantitative real-time polymerase chain reaction (PCR) targeted internal transcribed spacer (ITS) in ribosomal RNA gene at the initial visit and after 2 and 4 weeks of treatment. Assays showed that the average copy number of ITS DNA had significantly decreased to 22.9% at 2 weeks and 4.8% at 4 weeks compared with the initial visit. LLCZ topical treatment could defeat almost pathogenic dermatophytes in the scales within 4 weeks. Oxford University Press 2020-04 2019-05-21 /pmc/articles/PMC7108760/ /pubmed/31111903 http://dx.doi.org/10.1093/mmy/myz056 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Iwanaga, Tomoyuki
Ushigami, Tsuyoshi
Anzawa, Kazushi
Mochizuki, Takashi
Viability of pathogenic dermatophytes during a 4-week treatment with 1% topical luliconazole for tinea pedis
title Viability of pathogenic dermatophytes during a 4-week treatment with 1% topical luliconazole for tinea pedis
title_full Viability of pathogenic dermatophytes during a 4-week treatment with 1% topical luliconazole for tinea pedis
title_fullStr Viability of pathogenic dermatophytes during a 4-week treatment with 1% topical luliconazole for tinea pedis
title_full_unstemmed Viability of pathogenic dermatophytes during a 4-week treatment with 1% topical luliconazole for tinea pedis
title_short Viability of pathogenic dermatophytes during a 4-week treatment with 1% topical luliconazole for tinea pedis
title_sort viability of pathogenic dermatophytes during a 4-week treatment with 1% topical luliconazole for tinea pedis
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108760/
https://www.ncbi.nlm.nih.gov/pubmed/31111903
http://dx.doi.org/10.1093/mmy/myz056
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