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A model for HIV/AIDS pandemic with optimal control
Human immunodeficiency virus and acquired immune deficiency syndrome (HIV/AIDS) is pandemic. It has affected nearly 60 million people since the detection of the disease in 1981 to date. In this paper basic deterministic HIV/AIDS model with mass action incidence function are developed. Stability anal...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AIP Publishing LLC
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108779/ https://www.ncbi.nlm.nih.gov/pubmed/32255874 http://dx.doi.org/10.1063/1.4915640 |
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author | Sule, Amiru Abdullah, Farah Aini |
author_facet | Sule, Amiru Abdullah, Farah Aini |
author_sort | Sule, Amiru |
collection | PubMed |
description | Human immunodeficiency virus and acquired immune deficiency syndrome (HIV/AIDS) is pandemic. It has affected nearly 60 million people since the detection of the disease in 1981 to date. In this paper basic deterministic HIV/AIDS model with mass action incidence function are developed. Stability analysis is carried out. And the disease free equilibrium of the basic model was found to be locally asymptotically stable whenever the threshold parameter (RO) value is less than one, and unstable otherwise. The model is extended by introducing two optimal control strategies namely, CD4 counts and treatment for the infective using optimal control theory. Numerical simulation was carried out in order to illustrate the analytic results. |
format | Online Article Text |
id | pubmed-7108779 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | AIP Publishing LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-71087792020-04-01 A model for HIV/AIDS pandemic with optimal control Sule, Amiru Abdullah, Farah Aini AIP Conf Proc Contributed Oral Papers Human immunodeficiency virus and acquired immune deficiency syndrome (HIV/AIDS) is pandemic. It has affected nearly 60 million people since the detection of the disease in 1981 to date. In this paper basic deterministic HIV/AIDS model with mass action incidence function are developed. Stability analysis is carried out. And the disease free equilibrium of the basic model was found to be locally asymptotically stable whenever the threshold parameter (RO) value is less than one, and unstable otherwise. The model is extended by introducing two optimal control strategies namely, CD4 counts and treatment for the infective using optimal control theory. Numerical simulation was carried out in order to illustrate the analytic results. AIP Publishing LLC 2015-05-15 /pmc/articles/PMC7108779/ /pubmed/32255874 http://dx.doi.org/10.1063/1.4915640 Text en All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Contributed Oral Papers Sule, Amiru Abdullah, Farah Aini A model for HIV/AIDS pandemic with optimal control |
title | A model for HIV/AIDS pandemic with optimal control |
title_full | A model for HIV/AIDS pandemic with optimal control |
title_fullStr | A model for HIV/AIDS pandemic with optimal control |
title_full_unstemmed | A model for HIV/AIDS pandemic with optimal control |
title_short | A model for HIV/AIDS pandemic with optimal control |
title_sort | model for hiv/aids pandemic with optimal control |
topic | Contributed Oral Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108779/ https://www.ncbi.nlm.nih.gov/pubmed/32255874 http://dx.doi.org/10.1063/1.4915640 |
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