Angiopoietin-2 blockade ameliorates autoimmune neuroinflammation by inhibiting leukocyte recruitment into the CNS

Angiopoietin-2 (Ang2), a ligand of the endothelial Tie2 tyrosine kinase, is involved in vascular inflammation and leakage in critically ill patients. However, the role of Ang2 in demyelinating central nervous system (CNS) autoimmune diseases is unknown. Here, we report that Ang2 is critically involv...

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Detalles Bibliográficos
Autores principales: Li, Zhilin, Korhonen, Emilia A., Merlini, Arianna, Strauss, Judith, Wihuri, Eleonoora, Nurmi, Harri, Antila, Salli, Paech, Jennifer, Deutsch, Urban, Engelhardt, Britta, Chintharlapalli, Sudhakar, Koh, Gou Young, Flügel, Alexander, Alitalo, Kari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108925/
https://www.ncbi.nlm.nih.gov/pubmed/32149735
http://dx.doi.org/10.1172/JCI130308

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