The Mir181ab1 cluster promotes KRAS-driven oncogenesis and progression in lung and pancreas

Few therapies are currently available for patients with KRAS-driven cancers, highlighting the need to identify new molecular targets that modulate central downstream effector pathways. Here we found that the microRNA (miRNA) cluster including miR181ab1 is a key modulator of KRAS-driven oncogenesis....

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Detalles Bibliográficos
Autores principales: Valencia, Karmele, Erice, Oihane, Kostyrko, Kaja, Hausmann, Simone, Guruceaga, Elizabeth, Tathireddy, Anuradha, Flores, Natasha M., Sayles, Leanne C., Lee, Alex G., Fragoso, Rita, Sun, Tian-Qiang, Vallejo, Adrian, Roman, Marta, Entrialgo-Cadierno, Rodrigo, Migueliz, Itziar, Razquin, Nerea, Fortes, Puri, Lecanda, Fernando, Lu, Jun, Ponz-Sarvise, Mariano, Chen, Chang-Zheng, Mazur, Pawel K., Sweet-Cordero, E. Alejandro, Vicent, Silvestre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108928/
https://www.ncbi.nlm.nih.gov/pubmed/31874105
http://dx.doi.org/10.1172/JCI129012

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