Graft-versus-host disease reduces lymph node display of tissue-restricted self-antigens and promotes autoimmunity

Acute graft-versus-host disease (GVHD) is initially triggered by alloreactive T cells, which damage peripheral tissues and lymphoid organs. Subsequent transition to chronic GVHD involves the emergence of autoimmunity, although the underlying mechanisms driving this process are unclear. Here, we test...

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Detalles Bibliográficos
Autores principales: Dertschnig, Simone, Evans, Pamela, Santos e Sousa, Pedro, Manzo, Teresa, Ferrer, Ivana R., Stauss, Hans J., Bennett, Clare L., Chakraverty, Ronjon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108931/
https://www.ncbi.nlm.nih.gov/pubmed/31917684
http://dx.doi.org/10.1172/JCI133102

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