New frontiers in fertility preservation: a hypothesis on fertility optimization in men with hypergonadotrophic hypogonadism

Strategies exist that can mitigate the risk of causing iatrogenic infertility when men require testosterone replacement therapy (TRT). This article reviews the current medical therapies that preserve spermatogenesis when TRT is indicated. Furthermore, we highlight the re-emerging concept of hypothal...

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Detalles Bibliográficos
Autores principales: Herati, Amin S., Kohn, Taylor P., Kassiri, Borna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108987/
https://www.ncbi.nlm.nih.gov/pubmed/32257857
http://dx.doi.org/10.21037/tau.2019.12.39
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author Herati, Amin S.
Kohn, Taylor P.
Kassiri, Borna
author_facet Herati, Amin S.
Kohn, Taylor P.
Kassiri, Borna
author_sort Herati, Amin S.
collection PubMed
description Strategies exist that can mitigate the risk of causing iatrogenic infertility when men require testosterone replacement therapy (TRT). This article reviews the current medical therapies that preserve spermatogenesis when TRT is indicated. Furthermore, we highlight the re-emerging concept of hypothalamic-pituitary-gonadal (HPG) axis reset in hypergonadotrophic, hypogonadal infertile men who are planning sperm retrieval procedures. Finally, we present our hypothesis for a novel protocol to optimize hypergonadotrophic hypogonadal men before sperm extraction surgeries hormonally.
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spelling pubmed-71089872020-04-01 New frontiers in fertility preservation: a hypothesis on fertility optimization in men with hypergonadotrophic hypogonadism Herati, Amin S. Kohn, Taylor P. Kassiri, Borna Transl Androl Urol Review Article Strategies exist that can mitigate the risk of causing iatrogenic infertility when men require testosterone replacement therapy (TRT). This article reviews the current medical therapies that preserve spermatogenesis when TRT is indicated. Furthermore, we highlight the re-emerging concept of hypothalamic-pituitary-gonadal (HPG) axis reset in hypergonadotrophic, hypogonadal infertile men who are planning sperm retrieval procedures. Finally, we present our hypothesis for a novel protocol to optimize hypergonadotrophic hypogonadal men before sperm extraction surgeries hormonally. AME Publishing Company 2020-03 /pmc/articles/PMC7108987/ /pubmed/32257857 http://dx.doi.org/10.21037/tau.2019.12.39 Text en 2020 Translational Andrology and Urology. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Review Article
Herati, Amin S.
Kohn, Taylor P.
Kassiri, Borna
New frontiers in fertility preservation: a hypothesis on fertility optimization in men with hypergonadotrophic hypogonadism
title New frontiers in fertility preservation: a hypothesis on fertility optimization in men with hypergonadotrophic hypogonadism
title_full New frontiers in fertility preservation: a hypothesis on fertility optimization in men with hypergonadotrophic hypogonadism
title_fullStr New frontiers in fertility preservation: a hypothesis on fertility optimization in men with hypergonadotrophic hypogonadism
title_full_unstemmed New frontiers in fertility preservation: a hypothesis on fertility optimization in men with hypergonadotrophic hypogonadism
title_short New frontiers in fertility preservation: a hypothesis on fertility optimization in men with hypergonadotrophic hypogonadism
title_sort new frontiers in fertility preservation: a hypothesis on fertility optimization in men with hypergonadotrophic hypogonadism
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108987/
https://www.ncbi.nlm.nih.gov/pubmed/32257857
http://dx.doi.org/10.21037/tau.2019.12.39
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