Nintedanib inhibits intrahepatic cholangiocarcinoma aggressiveness via suppression of cytokines extracted from activated cancer-associated fibroblasts

BACKGROUND: Intrahepatic cholangiocarcinoma (ICC) is a malignancy that is challenging to treat. Fibroblasts in ICC tissues have been identified as cancer-associated fibroblasts (CAFs) that promote the malignant behaviour of ICC cells. An antifibrotic drug nintedanib has been reported to suppress act...

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Detalles Bibliográficos
Autores principales: Yamanaka, Takahiro, Harimoto, Norifumi, Yokobori, Takehiko, Muranushi, Ryo, Hoshino, Kouki, Hagiwara, Kei, Gantumur, Dolgormaa, Handa, Tadashi, Ishii, Norihiro, Tsukagoshi, Mariko, Igarashi, Takamichi, Tanaka, Hiroshi, Watanabe, Akira, Kubo, Norio, Araki, Kenichiro, Shirabe, Ken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109053/
https://www.ncbi.nlm.nih.gov/pubmed/32015511
http://dx.doi.org/10.1038/s41416-020-0744-7

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