Cargando…

Genetic 3′UTR variations and clinical factors significantly contribute to survival prediction and clinical response in breast cancer patients

The study describes a relationship between the 3′UTR variants, clinicopathological parameters and response to chemotherapy. We analyzed 33 germline polymorphisms in 3′UTRs of ADME genes in 305 breast cancer women treated with FAC regime. Clinical endpoints of this study were: overall survival (OS),...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pamuła-Piłat, Jolanta, Tęcza, Karolina, Kalinowska-Herok, Magdalena, Grzybowska, Ewa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109149/ https://www.ncbi.nlm.nih.gov/pubmed/32235849 http://dx.doi.org/10.1038/s41598-020-62662-z

Ejemplares similares

Genetic polymorphisms and response to 5-fluorouracil, doxorubicin and cyclophosphamide chemotherapy in breast cancer patients
por: Tecza, Karolina, et al.
Publicado: (2016)

Pharmacogenetics of FAC chemotherapy side effects in breast cancer patients
por: Tecza, Karolina, et al.
Publicado: (2015)

Genetic polymorphisms, efficiency and toxicity of cancer chemotherapy
por: Tecza, Karolina, et al.
Publicado: (2015)

Genetic polymorphisms and ovarian cancer risk and response to paclitaxel/cisplatin chemotherapy
por: Tecza, Karolina, et al.
Publicado: (2015)

Genetic polymorphisms and gene-dosage effect in ovarian cancer risk and response to paclitaxel/cisplatin chemotherapy
por: Tecza, Karolina, et al.
Publicado: (2015)

Copper transport system and response to ovarian cancer chemotherapy
por: Tecza, Karolina, et al.
Publicado: (2015)

Pharmacogenetics of toxicity of 5-fluorouracil, doxorubicin and cyclophosphamide chemotherapy in breast cancer patients
por: Tecza, Karolina, et al.
Publicado: (2018)

High-throughput genotyping of a common deletion polymorphism disrupting the TRY6 gene and its association with breast cancer risk
por: Wagner, Kerstin, et al.
Publicado: (2007)

Spectrum of tumors in the families with Hereditary Breast Ovarian Cancer syndrome carrying germline mutations in BRCA1 and 2 genes
por: Budryk, M, et al.
Publicado: (2012)

Functional Impact of Sequence Alterations Found in BRCA1 Promoter/5'UTR Region in Breast/Ovarian Cancer Families from Upper Silesia, Poland
por: Pamuła, Jolanta, et al.
Publicado: (2006)

Clinicopathological characteristics of breast cancer patients with NOD2 mutation according to age
por: Huszno, Joanna, et al.
Publicado: (2020)

Prevalence of the most frequent BRCA1 mutations in Polish population
por: Brozek, Izabela, et al.
Publicado: (2011)

Identification of novel sequence alterations and the functional analysis of the BRCA1 promoter/5'-UTR in families from Upper Silesia, Poland
por: Pamuła, J, et al.
Publicado: (2005)

Gene Expression Analysis in Ovarian Cancer – Faults and Hints from DNA Microarray Study
por: Lisowska, Katarzyna Marta, et al.
Publicado: (2014)

The putative oncogene, CRNDE, is a negative prognostic factor in ovarian cancer patients
por: Szafron, Lukasz Michal, et al.
Publicado: (2015)

Impact of Genetic Variation in TLR4 3′UTR on NSCLC Genetic Susceptibility
por: Wu, Hongjiao, et al.
Publicado: (2020)

Cell Death by Entosis: Triggers, Molecular Mechanisms and Clinical Significance
por: Kianfar, Mostafa, et al.
Publicado: (2022)

The Clinical Significance of Genetic Variation in Ovarian Cancer
por: Ban, Dongjo, et al.
Publicado: (2023)

Gene Expression Profiling in Hereditary, BRCA1-linked Breast Cancer: Preliminary Report
por: Dudaladava, Volha, et al.
Publicado: (2006)

Overall survival analysis of > 65-year-old patients with breast cancer based on their molecular, clinicopathological and laboratory factors
por: Huszno, Joanna, et al.
Publicado: (2022)

The Clinical and Biochemical Predictors of Bone Mass in Preterm Infants
por: Czech-Kowalska, Justyna, et al.
Publicado: (2016)

Chromatin-Directed Proteomics Identifies ZNF84 as a p53-Independent Regulator of p21 in Genotoxic Stress Response
por: Strzeszewska-Potyrała, Anna, et al.
Publicado: (2021)

Improved Autophagic Flux in Escapers from Doxorubicin-Induced Senescence/Polyploidy of Breast Cancer Cells
por: Bojko, Agnieszka, et al.
Publicado: (2020)

Variations within 3′-UTR of MDM4 gene contribute to clinical outcomes of advanced non-small cell lung cancer patients following platinum-based chemotherapy
por: Yang, Yang, et al.
Publicado: (2016)

Genetic Variation in VEGF Does Not Contribute Significantly to the Risk of Congenital Cardiovascular Malformation
por: Griffin, Helen R., et al.
Publicado: (2009)

Association of Genetic Variation in the 3'UTR of LHX6, IMMP2L, and AADAC With Tourette Syndrome
por: Pagliaroli, Luca, et al.
Publicado: (2020)

Biogenesis and Dynamics of Mitochondria during the Cell Cycle: Significance of 3′UTRs
por: Martínez-Diez, Marta, et al.
Publicado: (2006)

Polymorphisms of the FCN2 Gene 3’UTR Region and Their Clinical Associations in Preterm Newborns
por: Świerzko, Anna S., et al.
Publicado: (2021)

M1-like macrophages change tumor blood vessels and microenvironment in murine melanoma
por: Jarosz-Biej, Magdalena, et al.
Publicado: (2018)

Hidden Genetic Variation in LCA9‐Associated Congenital Blindness Explained by 5′UTR Mutations and Copy‐Number Variations of NMNAT1
por: Coppieters, Frauke, et al.
Publicado: (2015)

Genetic Variation in BCL2 3′-UTR Was Associated with Lung Cancer Risk and Prognosis in Male Chinese Population
por: Xu, Ping, et al.
Publicado: (2013)

Non-additive genetic components contribute significantly to population-wide gene expression variation
por: Tsouris, Andreas, et al.
Publicado: (2023)

Associations of CXCL1 gene 5’UTR variations with ovarian cancer
por: Guo, Man, et al.
Publicado: (2020)

Radiotherapy-related changes in serum proteome patterns of head and neck cancer patients; the effect of low and medium doses of radiation delivered to large volumes of normal tissue
por: Widłak, Piotr, et al.
Publicado: (2013)

Disrupting interaction between miR-132 and Mmp9 3′UTR improves synaptic plasticity and memory in mice
por: Kuzniewska, Bozena, et al.
Publicado: (2022)

Hairpin structure within the 3′UTR of DNA polymerase β mRNA acts as a post-transcriptional regulatory element and interacts with Hax-1
por: Sarnowska, Elżbieta, et al.
Publicado: (2007)

Variants in the 5′UTR reduce SHOX expression and contribute to SHOX haploinsufficiency
por: Babu, Deepak, et al.
Publicado: (2020)

Contribution of FKBP5 Genetic Variation to Gemcitabine Treatment and Survival in Pancreatic Adenocarcinoma
por: Ellsworth, Katarzyna A., et al.
Publicado: (2013)

Streamlining differential exon and 3′ UTR usage with diffUTR
por: Gerber, Stefan, et al.
Publicado: (2021)

Frequency of HLA‑G UTR‑1/UTR‑3/UTR‑7 in women with unexplained recurrent spontaneous abortion
por: Bai, Wei, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_bser52ge5c1m9d2he2k7is3h1c