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Actin–tropomyosin distribution in non-muscle cells
The interactions of cytoskeletal actin filaments with myosin family motors are essential for the integrity and function of eukaryotic cells. They support a wide range of force-dependent functions. These include mechano-transduction, directed transcellular transport processes, barrier functions, cyto...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109190/ https://www.ncbi.nlm.nih.gov/pubmed/31054005 http://dx.doi.org/10.1007/s10974-019-09514-0 |
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author | Manstein, Dietmar J. Meiring, J. C. M. Hardeman, E. C. Gunning, Peter W. |
author_facet | Manstein, Dietmar J. Meiring, J. C. M. Hardeman, E. C. Gunning, Peter W. |
author_sort | Manstein, Dietmar J. |
collection | PubMed |
description | The interactions of cytoskeletal actin filaments with myosin family motors are essential for the integrity and function of eukaryotic cells. They support a wide range of force-dependent functions. These include mechano-transduction, directed transcellular transport processes, barrier functions, cytokinesis, and cell migration. Despite the indispensable role of tropomyosins in the generation and maintenance of discrete actomyosin-based structures, the contribution of individual cytoskeletal tropomyosin isoforms to the structural and functional diversification of the actin cytoskeleton remains a work in progress. Here, we review processes that contribute to the dynamic sorting and targeted distribution of tropomyosin isoforms in the formation of discrete actomyosin-based structures in animal cells and their effects on actin-based motility and contractility. |
format | Online Article Text |
id | pubmed-7109190 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-71091902020-04-06 Actin–tropomyosin distribution in non-muscle cells Manstein, Dietmar J. Meiring, J. C. M. Hardeman, E. C. Gunning, Peter W. J Muscle Res Cell Motil Article The interactions of cytoskeletal actin filaments with myosin family motors are essential for the integrity and function of eukaryotic cells. They support a wide range of force-dependent functions. These include mechano-transduction, directed transcellular transport processes, barrier functions, cytokinesis, and cell migration. Despite the indispensable role of tropomyosins in the generation and maintenance of discrete actomyosin-based structures, the contribution of individual cytoskeletal tropomyosin isoforms to the structural and functional diversification of the actin cytoskeleton remains a work in progress. Here, we review processes that contribute to the dynamic sorting and targeted distribution of tropomyosin isoforms in the formation of discrete actomyosin-based structures in animal cells and their effects on actin-based motility and contractility. Springer International Publishing 2019-05-04 2020 /pmc/articles/PMC7109190/ /pubmed/31054005 http://dx.doi.org/10.1007/s10974-019-09514-0 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Article Manstein, Dietmar J. Meiring, J. C. M. Hardeman, E. C. Gunning, Peter W. Actin–tropomyosin distribution in non-muscle cells |
title | Actin–tropomyosin distribution in non-muscle cells |
title_full | Actin–tropomyosin distribution in non-muscle cells |
title_fullStr | Actin–tropomyosin distribution in non-muscle cells |
title_full_unstemmed | Actin–tropomyosin distribution in non-muscle cells |
title_short | Actin–tropomyosin distribution in non-muscle cells |
title_sort | actin–tropomyosin distribution in non-muscle cells |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109190/ https://www.ncbi.nlm.nih.gov/pubmed/31054005 http://dx.doi.org/10.1007/s10974-019-09514-0 |
work_keys_str_mv | AT mansteindietmarj actintropomyosindistributioninnonmusclecells AT meiringjcm actintropomyosindistributioninnonmusclecells AT hardemanec actintropomyosindistributioninnonmusclecells AT gunningpeterw actintropomyosindistributioninnonmusclecells |