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Roles of G protein-coupled receptors in inflammatory bowel disease
Inflammatory bowel disease (IBD) is a complex disease with multiple pathogenic factors. Although the pathogenesis of IBD is still unclear, a current hypothesis suggests that genetic susceptibility, environmental factors, a dysfunctional immune system, the microbiome, and the interactions of these fa...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109274/ https://www.ncbi.nlm.nih.gov/pubmed/32256014 http://dx.doi.org/10.3748/wjg.v26.i12.1242 |
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author | Zeng, Zhen Mukherjee, Arjudeb Varghese, Adwin Pidiyath Yang, Xiao-Li Chen, Sha Zhang, Hu |
author_facet | Zeng, Zhen Mukherjee, Arjudeb Varghese, Adwin Pidiyath Yang, Xiao-Li Chen, Sha Zhang, Hu |
author_sort | Zeng, Zhen |
collection | PubMed |
description | Inflammatory bowel disease (IBD) is a complex disease with multiple pathogenic factors. Although the pathogenesis of IBD is still unclear, a current hypothesis suggests that genetic susceptibility, environmental factors, a dysfunctional immune system, the microbiome, and the interactions of these factors substantially contribute to the occurrence and development of IBD. Although existing and emerging drugs have been proven to be effective in treating IBD, none can cure IBD permanently. G protein-coupled receptors (GPCRs) are critical signaling molecules implicated in the immune response, cell proliferation, inflammation regulation and intestinal barrier maintenance. Breakthroughs in the understanding of the structures and functions of GPCRs have provided a driving force for exploring the roles of GPCRs in the pathogenesis of diseases, thereby leading to the development of GPCR-targeted medication. To date, a number of GPCRs have been shown to be associated with IBD, significantly advancing the drug discovery process for IBD. The associations between GPCRs and disease activity, disease severity, and disease phenotypes have also paved new avenues for the precise management of patients with IBD. In this review, we mainly focus on the roles of the most studied proton-sensing GPCRs, cannabinoid receptors, and estrogen-related GPCRs in the pathogenesis of IBD and their potential clinical values in IBD and some other diseases. |
format | Online Article Text |
id | pubmed-7109274 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-71092742020-04-03 Roles of G protein-coupled receptors in inflammatory bowel disease Zeng, Zhen Mukherjee, Arjudeb Varghese, Adwin Pidiyath Yang, Xiao-Li Chen, Sha Zhang, Hu World J Gastroenterol Review Inflammatory bowel disease (IBD) is a complex disease with multiple pathogenic factors. Although the pathogenesis of IBD is still unclear, a current hypothesis suggests that genetic susceptibility, environmental factors, a dysfunctional immune system, the microbiome, and the interactions of these factors substantially contribute to the occurrence and development of IBD. Although existing and emerging drugs have been proven to be effective in treating IBD, none can cure IBD permanently. G protein-coupled receptors (GPCRs) are critical signaling molecules implicated in the immune response, cell proliferation, inflammation regulation and intestinal barrier maintenance. Breakthroughs in the understanding of the structures and functions of GPCRs have provided a driving force for exploring the roles of GPCRs in the pathogenesis of diseases, thereby leading to the development of GPCR-targeted medication. To date, a number of GPCRs have been shown to be associated with IBD, significantly advancing the drug discovery process for IBD. The associations between GPCRs and disease activity, disease severity, and disease phenotypes have also paved new avenues for the precise management of patients with IBD. In this review, we mainly focus on the roles of the most studied proton-sensing GPCRs, cannabinoid receptors, and estrogen-related GPCRs in the pathogenesis of IBD and their potential clinical values in IBD and some other diseases. Baishideng Publishing Group Inc 2020-03-28 2020-03-28 /pmc/articles/PMC7109274/ /pubmed/32256014 http://dx.doi.org/10.3748/wjg.v26.i12.1242 Text en ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Review Zeng, Zhen Mukherjee, Arjudeb Varghese, Adwin Pidiyath Yang, Xiao-Li Chen, Sha Zhang, Hu Roles of G protein-coupled receptors in inflammatory bowel disease |
title | Roles of G protein-coupled receptors in inflammatory bowel disease |
title_full | Roles of G protein-coupled receptors in inflammatory bowel disease |
title_fullStr | Roles of G protein-coupled receptors in inflammatory bowel disease |
title_full_unstemmed | Roles of G protein-coupled receptors in inflammatory bowel disease |
title_short | Roles of G protein-coupled receptors in inflammatory bowel disease |
title_sort | roles of g protein-coupled receptors in inflammatory bowel disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109274/ https://www.ncbi.nlm.nih.gov/pubmed/32256014 http://dx.doi.org/10.3748/wjg.v26.i12.1242 |
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