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PDK4‐Deficiency Reprograms Intrahepatic Glucose and Lipid Metabolism to Facilitate Liver Regeneration in Mice

Liver regeneration requires intrahepatic and extrahepatic metabolic reprogramming to meet the high hepatic bioenergy demand for liver cell repopulation. This study aims to elucidate how pyruvate dehydrogenase kinase 4 (PDK4), a critical regulator of glucose and lipid metabolism, coordinates metaboli...

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Detalles Bibliográficos
Autores principales: Zhao, Yulan, Tran, Melanie, Wang, Li, Shin, Dong‐Ju, Wu, Jianguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109344/
https://www.ncbi.nlm.nih.gov/pubmed/32258946
http://dx.doi.org/10.1002/hep4.1484