Cargando…
Preclinical Evaluation of Radiation-Induced Toxicity in Targeted Alpha Therapy Using [(211)At] NaAt in Mice: A Revisit()
We recently reported the dose-dependent therapeutic effect of (211)At-NaAt in differentiated thyroid cancer xenograft models. In the present study, we evaluated the radiation-induced toxicity of (211)At-NaAt using detailed hematological, biochemical, and histological analyses. Biodistribution of (21...
Autores principales: | Liu, Yuwei, Watabe, Tadashi, Kaneda-Nakashima, Kazuko, Ooe, Kazuhiro, Shirakami, Yoshifumi, Toyoshima, Atsushi, Shimosegawa, Eku, Nakano, Takashi, Shinohara, Atsushi, Hatazawa, Jun |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Neoplasia Press
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109464/ https://www.ncbi.nlm.nih.gov/pubmed/32220762 http://dx.doi.org/10.1016/j.tranon.2020.100757 |
Ejemplares similares
-
Comparison of the Therapeutic Effects of [(211)At]NaAt and [(131)I]NaI in an NIS-Expressing Thyroid Cancer Mouse Model
por: Watabe, Tadashi, et al.
Publicado: (2022) -
Targeted alpha therapy using astatine ((211)At)-labeled phenylalanine: A preclinical study in glioma bearing mice
por: Watabe, Tadashi, et al.
Publicado: (2020) -
Enhancement of (211)At Uptake via the Sodium Iodide Symporter by the Addition of Ascorbic Acid in Targeted α-Therapy of Thyroid Cancer
por: Watabe, Tadashi, et al.
Publicado: (2019) -
Synthesis of [(211)At]4-astato-L-phenylalanine by dihydroxyboryl-astatine substitution reaction in aqueous solution
por: Shirakami, Yoshifumi, et al.
Publicado: (2021) -
Extended single-dose toxicity study of [(211)At]NaAt in mice for the first-in-human clinical trial of targeted alpha therapy for differentiated thyroid cancer
por: Watabe, Tadashi, et al.
Publicado: (2021)