Pregnane steroidogenesis is altered by HIV-1 Tat and morphine: Physiological allopregnanolone is protective against neurotoxic and psychomotor effects

Pregnane steroids, particularly allopregnanolone (AlloP), are neuroprotective in response to central insult. While unexplored in vivo, AlloP may confer protection against the neurological dysfunction associated with human immunodeficiency virus type 1 (HIV-1). The HIV-1 regulatory protein, trans-act...

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Detalles Bibliográficos
Autores principales: Paris, Jason J., Liere, Philippe, Kim, Sarah, Mahdi, Fakhri, Buchanan, Meagan E., Nass, Sara R., Qrareya, Alaa N., Salahuddin, Mohammed F., Pianos, Antoine, Fernandez, Neïké, Shariat-Madar, Zia, Knapp, Pamela E., Schumacher, Michael, Hauser, Kurt F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Articles from the Special Issue on Allopregnanolone role in the neurobiology of stress and mood disorders; Edited by Graziano Pinna
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109513/
https://www.ncbi.nlm.nih.gov/pubmed/32258256
http://dx.doi.org/10.1016/j.ynstr.2020.100211

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