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Effect of Zolpidem in the Aftermath of Traumatic Brain Injury: An MEG Study

In the past two decades, many studies have shown the paradoxical efficacy of zolpidem, a hypnotic used to induce sleep, in transiently alleviating various disorders of consciousness such as traumatic brain injury (TBI), dystonia, and Parkinson's disease. The mechanism of action of this effect o...

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Autores principales: Sripad, Praveen, Rosenberg, Jessica, Boers, Frank, Filss, Christian P., Galldiks, Norbert, Langen, Karl-Josef, Clauss, Ralf, Shah, N. Jon, Dammers, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109561/
https://www.ncbi.nlm.nih.gov/pubmed/32257474
http://dx.doi.org/10.1155/2020/8597062
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author Sripad, Praveen
Rosenberg, Jessica
Boers, Frank
Filss, Christian P.
Galldiks, Norbert
Langen, Karl-Josef
Clauss, Ralf
Shah, N. Jon
Dammers, Jürgen
author_facet Sripad, Praveen
Rosenberg, Jessica
Boers, Frank
Filss, Christian P.
Galldiks, Norbert
Langen, Karl-Josef
Clauss, Ralf
Shah, N. Jon
Dammers, Jürgen
author_sort Sripad, Praveen
collection PubMed
description In the past two decades, many studies have shown the paradoxical efficacy of zolpidem, a hypnotic used to induce sleep, in transiently alleviating various disorders of consciousness such as traumatic brain injury (TBI), dystonia, and Parkinson's disease. The mechanism of action of this effect of zolpidem is of great research interest. In this case study, we use magnetoencephalography (MEG) to investigate a fully conscious, ex-coma patient who suffered from neurological difficulties for a few years due to traumatic brain injury. For a few years after injury, the patient was under medication with zolpidem that drastically improved his symptoms. MEG recordings taken before and after zolpidem showed a reduction in power in the theta-alpha (4–12 Hz) and lower beta (15–20 Hz) frequency bands. An increase in power after zolpidem intake was found in the higher beta/lower gamma (20–43 Hz) frequency band. Source level functional connectivity measured using weighted-phase lag index showed changes after zolpidem intake. Stronger connectivity between left frontal and temporal brain regions was observed. We report that zolpidem induces a change in MEG resting power and functional connectivity in the patient. MEG is an informative and sensitive tool to detect changes in brain activity for TBI.
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spelling pubmed-71095612020-04-06 Effect of Zolpidem in the Aftermath of Traumatic Brain Injury: An MEG Study Sripad, Praveen Rosenberg, Jessica Boers, Frank Filss, Christian P. Galldiks, Norbert Langen, Karl-Josef Clauss, Ralf Shah, N. Jon Dammers, Jürgen Case Rep Neurol Med Case Report In the past two decades, many studies have shown the paradoxical efficacy of zolpidem, a hypnotic used to induce sleep, in transiently alleviating various disorders of consciousness such as traumatic brain injury (TBI), dystonia, and Parkinson's disease. The mechanism of action of this effect of zolpidem is of great research interest. In this case study, we use magnetoencephalography (MEG) to investigate a fully conscious, ex-coma patient who suffered from neurological difficulties for a few years due to traumatic brain injury. For a few years after injury, the patient was under medication with zolpidem that drastically improved his symptoms. MEG recordings taken before and after zolpidem showed a reduction in power in the theta-alpha (4–12 Hz) and lower beta (15–20 Hz) frequency bands. An increase in power after zolpidem intake was found in the higher beta/lower gamma (20–43 Hz) frequency band. Source level functional connectivity measured using weighted-phase lag index showed changes after zolpidem intake. Stronger connectivity between left frontal and temporal brain regions was observed. We report that zolpidem induces a change in MEG resting power and functional connectivity in the patient. MEG is an informative and sensitive tool to detect changes in brain activity for TBI. Hindawi 2020-03-20 /pmc/articles/PMC7109561/ /pubmed/32257474 http://dx.doi.org/10.1155/2020/8597062 Text en Copyright © 2020 Praveen Sripad et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Sripad, Praveen
Rosenberg, Jessica
Boers, Frank
Filss, Christian P.
Galldiks, Norbert
Langen, Karl-Josef
Clauss, Ralf
Shah, N. Jon
Dammers, Jürgen
Effect of Zolpidem in the Aftermath of Traumatic Brain Injury: An MEG Study
title Effect of Zolpidem in the Aftermath of Traumatic Brain Injury: An MEG Study
title_full Effect of Zolpidem in the Aftermath of Traumatic Brain Injury: An MEG Study
title_fullStr Effect of Zolpidem in the Aftermath of Traumatic Brain Injury: An MEG Study
title_full_unstemmed Effect of Zolpidem in the Aftermath of Traumatic Brain Injury: An MEG Study
title_short Effect of Zolpidem in the Aftermath of Traumatic Brain Injury: An MEG Study
title_sort effect of zolpidem in the aftermath of traumatic brain injury: an meg study
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109561/
https://www.ncbi.nlm.nih.gov/pubmed/32257474
http://dx.doi.org/10.1155/2020/8597062
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