Spermine synthesis inhibitor blocks 25-hydroxycholesterol-induced- apoptosis via SREBP2 upregulation in DLD-1 cell spheroids

The oxysterol 25-hydroxycholesterol (25-HC) has diverse physiological activities, including the ability to inhibit anchorage-independent growth of colorectal cancer cells. Here, we found that a polyamine synthesis inhibitor, DFMO, prevented 25-HC-induced apoptosis in non-anchored colorectal cancer D...

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Detalles Bibliográficos
Autores principales: Kakimoto, Miku, Yamamoto, Hideya, Tanaka, Arowu R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109571/
https://www.ncbi.nlm.nih.gov/pubmed/32258442
http://dx.doi.org/10.1016/j.bbrep.2020.100754

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