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The role of neuraminidase 1 and 2 in glycoprotein Ibα-mediated integrin αIIbβ3 activation

Upon vascular injury, platelets adhere to von Willebrand Factor (VWF) via glycoprotein Ibα (GPIbα). GPIbα contains many glycans, capped by sialic acid. Sialic acid cleavage (desialylation) triggers clearance of platelets. Neuraminidases (NEU) are responsible for desialylation and so far, NEU1-4 have...

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Detalles Bibliográficos
Autores principales:	van der Wal, Dianne E., Davis, April M., Mach, Melanie, Marks, Denese C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ferrata Storti Foundation 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109719/ https://www.ncbi.nlm.nih.gov/pubmed/31273092 http://dx.doi.org/10.3324/haematol.2019.215830

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