RUNX3 levels in human hematopoietic progenitors are regulated by aging and dictate erythroid-myeloid balance

Healthy bone marrow progenitors yield a co-ordinated balance of hematopoietic lineages. This balance shifts with aging toward enhanced granulopoiesis with diminished erythropoiesis and lymphopoiesis, changes which likely contribute to the development of bone marrow disorders in the elderly. In this...

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Detalles Bibliográficos
Autores principales: Balogh, Peter, Adelman, Emmalee R., Pluvinage, John V., Capaldo, Brian J., Freeman, Katie C., Singh, Sandeep, Elagib, Kamaleldin E., Nakamura, Yukio, Kurita, Ryo, Sashida, Goro, Zunder, Eli R., Li, Hui, Gru, Alejandro A., Price, Elizabeth A., Schrier, Stanley L., Weissman, Irving L., Figueroa, Maria E., Pang, Wendy W., Goldfarb, Adam N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109730/
https://www.ncbi.nlm.nih.gov/pubmed/31171641
http://dx.doi.org/10.3324/haematol.2018.208918

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