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EZH2 inhibitors abrogate upregulation of trimethylation of H3K27 by CDK9 inhibitors and potentiate its activity against diffuse large B-cell lymphoma

Aberrant expression of CDK9/cyclin T1 has been found in diffuse large B-cell lymphoma (DLBCL), and suggests that CDK9 is a potential therapeutic target for DLBCL. Here, we firstly demonstrated that CDKI-73, a novel cyclin-dependent kinases (CDK) inhibitor, potently blocks CDK9, triggered apoptosis a...

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Detalles Bibliográficos
Autores principales:	Xie, Shao, Wei, Fan, Sun, Yi-ming, Gao, Ying-lei, Pan, Lu-lu, Tan, Min-jia, Wang, Shu-dong, Ding, Jian, Chen, Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ferrata Storti Foundation 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109751/ https://www.ncbi.nlm.nih.gov/pubmed/31289198 http://dx.doi.org/10.3324/haematol.2019.222935

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