HIF-1α is over-expressed in leukemic cells from TP53-disrupted patients and is a promising therapeutic target in chronic lymphocytic leukemia

In chronic lymphocytic leukemia (CLL), the hypoxia-inducible factor 1 (HIF-1) regulates the response of tumor cells to hypoxia and their protective interactions with the leukemic microenvironment. In this study, we demonstrate that CLL cells from TP53-disrupted (TP53(dis)) patients have constitutive...

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Detalles Bibliográficos
Autores principales: Griggio, Valentina, Vitale, Candida, Todaro, Maria, Riganti, Chiara, Kopecka, Joanna, Salvetti, Chiara, Bomben, Riccardo, Bo, Michele Dal, Magliulo, Daniela, Rossi, Davide, Pozzato, Gabriele, Bonello, Lisa, Marchetti, Monia, Omedè, Paola, Kodipad, Ahad Ahmed, Laurenti, Luca, Del Poeta, Giovanni, Mauro, Francesca Romana, Bernardi, Rosa, Zenz, Thorsten, Gattei, Valter, Gaidano, Gianluca, Foà, Robin, Massaia, Massimo, Boccadoro, Mario, Coscia, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109756/
https://www.ncbi.nlm.nih.gov/pubmed/31289209
http://dx.doi.org/10.3324/haematol.2019.217430

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