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Coronaviren: von der banalen Erkältung zum schweren Lungenversagen: Chronologie einer Pandemie

In December 2019 a new human coronavirus emerged in Wuhan, China, which is known as SARS-CoV‑2. The clinical course of the disease known as coronavirus disease 2019 (COVID-19) ranges from mild respiratory symptoms to severe lung failure. The virus is currently rapidly spreading around the world and...

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Autores principales: Hufert, F., Spiegel, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Medizin 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110433/
https://www.ncbi.nlm.nih.gov/pubmed/32292213
http://dx.doi.org/10.1007/s00112-020-00910-2
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author Hufert, F.
Spiegel, M.
author_facet Hufert, F.
Spiegel, M.
author_sort Hufert, F.
collection PubMed
description In December 2019 a new human coronavirus emerged in Wuhan, China, which is known as SARS-CoV‑2. The clinical course of the disease known as coronavirus disease 2019 (COVID-19) ranges from mild respiratory symptoms to severe lung failure. The virus is currently rapidly spreading around the world and pushing health systems to the limits of their capacity due to the exponential increase in the number of cases. The origin of SARS-CoV‑2 lies in the bat coronavirus pool and has now emerged in the human population due to interspecies transmission. Molecular diagnostic methods have been established in a very short time and a number of clinical studies on the effectiveness of different antiviral drugs are ongoing. The development of a vaccine using different approaches is also under investigation. Considering the high number of cases and mortality rates of up to 9% there is an urgent need for action. This article summarizes the current state of knowledge on human coronaviruses with a strong focus on the current data on SARS-CoV‑2. Due to the daily changing level of knowledge, the article reflects the status up to 21 March 2020.
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spelling pubmed-71104332020-04-01 Coronaviren: von der banalen Erkältung zum schweren Lungenversagen: Chronologie einer Pandemie Hufert, F. Spiegel, M. Monatsschr Kinderheilkd Leitthema In December 2019 a new human coronavirus emerged in Wuhan, China, which is known as SARS-CoV‑2. The clinical course of the disease known as coronavirus disease 2019 (COVID-19) ranges from mild respiratory symptoms to severe lung failure. The virus is currently rapidly spreading around the world and pushing health systems to the limits of their capacity due to the exponential increase in the number of cases. The origin of SARS-CoV‑2 lies in the bat coronavirus pool and has now emerged in the human population due to interspecies transmission. Molecular diagnostic methods have been established in a very short time and a number of clinical studies on the effectiveness of different antiviral drugs are ongoing. The development of a vaccine using different approaches is also under investigation. Considering the high number of cases and mortality rates of up to 9% there is an urgent need for action. This article summarizes the current state of knowledge on human coronaviruses with a strong focus on the current data on SARS-CoV‑2. Due to the daily changing level of knowledge, the article reflects the status up to 21 March 2020. Springer Medizin 2020-04-01 2020 /pmc/articles/PMC7110433/ /pubmed/32292213 http://dx.doi.org/10.1007/s00112-020-00910-2 Text en © Springer Medizin Verlag GmbH, ein Teil von Springer Nature 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Leitthema
Hufert, F.
Spiegel, M.
Coronaviren: von der banalen Erkältung zum schweren Lungenversagen: Chronologie einer Pandemie
title Coronaviren: von der banalen Erkältung zum schweren Lungenversagen: Chronologie einer Pandemie
title_full Coronaviren: von der banalen Erkältung zum schweren Lungenversagen: Chronologie einer Pandemie
title_fullStr Coronaviren: von der banalen Erkältung zum schweren Lungenversagen: Chronologie einer Pandemie
title_full_unstemmed Coronaviren: von der banalen Erkältung zum schweren Lungenversagen: Chronologie einer Pandemie
title_short Coronaviren: von der banalen Erkältung zum schweren Lungenversagen: Chronologie einer Pandemie
title_sort coronaviren: von der banalen erkältung zum schweren lungenversagen: chronologie einer pandemie
topic Leitthema
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110433/
https://www.ncbi.nlm.nih.gov/pubmed/32292213
http://dx.doi.org/10.1007/s00112-020-00910-2
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