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Cough induced by airway vibration as a model of airway hyperreactivity in patients with acute upper respiratory tract infection
Patients with acute upper respiratory tract infection (URTI) have been shown to be hyperreactive to inhaled tussigens such as citric acid and capsaicin, and the authors propose that this may be due to an increased sensitivity of airway receptors that mediate cough. In recent studies we have demonstr...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Ltd.
2004
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110439/ https://www.ncbi.nlm.nih.gov/pubmed/15564072 http://dx.doi.org/10.1016/j.pupt.2004.09.011 |
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author | Eccles, R. Lee, P.C.L. |
author_facet | Eccles, R. Lee, P.C.L. |
author_sort | Eccles, R. |
collection | PubMed |
description | Patients with acute upper respiratory tract infection (URTI) have been shown to be hyperreactive to inhaled tussigens such as citric acid and capsaicin, and the authors propose that this may be due to an increased sensitivity of airway receptors that mediate cough. In recent studies we have demonstrated that cough may be induced by vibration of the airway at the level of the throat or chest in patients with URTI but that the same stimuli induce little or no cough in healthy subjects. The difference between the patients with URTI and healthy subjects in their response to airway vibration may be explained on the basis of hyperreactivity of airway sensory receptors. We propose that the model of cough induced by airway vibration may be useful for studies on the pathophysiology and pharmacology of airway hyperreactivity in acute cough. The airway vibration model of cough may have some advantages over inhaled tussigens as the stimulus is easily controlled and the method is safe for use in children. |
format | Online Article Text |
id | pubmed-7110439 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2004 |
publisher | Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71104392020-04-02 Cough induced by airway vibration as a model of airway hyperreactivity in patients with acute upper respiratory tract infection Eccles, R. Lee, P.C.L. Pulm Pharmacol Ther Article Patients with acute upper respiratory tract infection (URTI) have been shown to be hyperreactive to inhaled tussigens such as citric acid and capsaicin, and the authors propose that this may be due to an increased sensitivity of airway receptors that mediate cough. In recent studies we have demonstrated that cough may be induced by vibration of the airway at the level of the throat or chest in patients with URTI but that the same stimuli induce little or no cough in healthy subjects. The difference between the patients with URTI and healthy subjects in their response to airway vibration may be explained on the basis of hyperreactivity of airway sensory receptors. We propose that the model of cough induced by airway vibration may be useful for studies on the pathophysiology and pharmacology of airway hyperreactivity in acute cough. The airway vibration model of cough may have some advantages over inhaled tussigens as the stimulus is easily controlled and the method is safe for use in children. Elsevier Ltd. 2004-12 2004-11-02 /pmc/articles/PMC7110439/ /pubmed/15564072 http://dx.doi.org/10.1016/j.pupt.2004.09.011 Text en Copyright © 2004 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Eccles, R. Lee, P.C.L. Cough induced by airway vibration as a model of airway hyperreactivity in patients with acute upper respiratory tract infection |
title | Cough induced by airway vibration as a model of airway hyperreactivity in patients with acute upper respiratory tract infection |
title_full | Cough induced by airway vibration as a model of airway hyperreactivity in patients with acute upper respiratory tract infection |
title_fullStr | Cough induced by airway vibration as a model of airway hyperreactivity in patients with acute upper respiratory tract infection |
title_full_unstemmed | Cough induced by airway vibration as a model of airway hyperreactivity in patients with acute upper respiratory tract infection |
title_short | Cough induced by airway vibration as a model of airway hyperreactivity in patients with acute upper respiratory tract infection |
title_sort | cough induced by airway vibration as a model of airway hyperreactivity in patients with acute upper respiratory tract infection |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110439/ https://www.ncbi.nlm.nih.gov/pubmed/15564072 http://dx.doi.org/10.1016/j.pupt.2004.09.011 |
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