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A single amino acid substitution in the S1 and S2 Spike protein domains determines the neutralization escape phenotype of SARS-CoV

In response to SARS-CoV infection, neutralizing antibodies are generated against the Spike (S) protein. Determination of the active regions that allow viral escape from neutralization would enable the use of these antibodies for future passive immunotherapy. We immunized mice with UV-inactivated SAR...

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Detalles Bibliográficos
Autores principales:	Mitsuki, Yu-ya, Ohnishi, Kazuo, Takagi, Hirotaka, Oshima, Masamichi, Yamamoto, Takuya, Mizukoshi, Fuminori, Terahara, Kazutaka, Kobayashi, Kazuo, Yamamoto, Naoki, Yamaoka, Shoji, Tsunetsugu-Yokota, Yasuko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Masson SAS. 2008
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110505/ https://www.ncbi.nlm.nih.gov/pubmed/18606245 http://dx.doi.org/10.1016/j.micinf.2008.05.009

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