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CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma
BACKGROUND: Long non-coding RNAs (lncRNAs) exhibit highly cell type-specific expression and function, making this class of transcript attractive for targeted cancer therapy. However, the vast majority of lncRNAs have not been tested as potential therapeutic targets, particularly in the context of cu...
Autores principales: | Liu, S. John, Malatesta, Martina, Lien, Brian V., Saha, Parna, Thombare, Shivani S., Hong, Sung Jun, Pedraza, Leslie, Koontz, Mark, Seo, Kyounghee, Horlbeck, Max A., He, Daniel, Birk, Harjus S., Jain, Miten, Olsen, Hugh E., Akeson, Mark, Weissman, Jonathan S., Monje, Michelle, Gupta, Nalin, Raleigh, David R., Ullian, Erik M., Lim, Daniel A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110660/ https://www.ncbi.nlm.nih.gov/pubmed/32234056 http://dx.doi.org/10.1186/s13059-020-01995-4 |
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