Therapeutic Options for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) – possible lessons from a systematic review of SARS-CoV therapy

The Middle East Respiratory Syndrome coronavirus (MERS-CoV) has been detected in a number of countries in the Middle East and Europe with an apparently high mortality rate. It is phylogenetically related to the SARS coronavirus and has also been associated with severe respiratory illness as well as...

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Autores principales: Momattin, Hisham, Mohammed, Khurram, Zumla, Alimuddin, Memish, Ziad A., Al-Tawfiq, Jaffar A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Society for Infectious Diseases. Published by Elsevier Ltd. 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110699/
https://www.ncbi.nlm.nih.gov/pubmed/23993766
http://dx.doi.org/10.1016/j.ijid.2013.07.002
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author Momattin, Hisham
Mohammed, Khurram
Zumla, Alimuddin
Memish, Ziad A.
Al-Tawfiq, Jaffar A.
author_facet Momattin, Hisham
Mohammed, Khurram
Zumla, Alimuddin
Memish, Ziad A.
Al-Tawfiq, Jaffar A.
author_sort Momattin, Hisham
collection PubMed
description The Middle East Respiratory Syndrome coronavirus (MERS-CoV) has been detected in a number of countries in the Middle East and Europe with an apparently high mortality rate. It is phylogenetically related to the SARS coronavirus and has also been associated with severe respiratory illness as well as nosocomial transmission in healthcare settings. Current international recommendations do not support any specific therapies; however, there are a number of agents, which were used during the SARS epidemic of 2003. It is possible that these might be active against the related MERS coronavirus. We have reviewed the literature on the safety and efficacy of therapies used in patients with SARS with a view to their potential use in patients with MERS-CoV infections.
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spelling pubmed-71106992020-04-02 Therapeutic Options for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) – possible lessons from a systematic review of SARS-CoV therapy Momattin, Hisham Mohammed, Khurram Zumla, Alimuddin Memish, Ziad A. Al-Tawfiq, Jaffar A. Int J Infect Dis Article The Middle East Respiratory Syndrome coronavirus (MERS-CoV) has been detected in a number of countries in the Middle East and Europe with an apparently high mortality rate. It is phylogenetically related to the SARS coronavirus and has also been associated with severe respiratory illness as well as nosocomial transmission in healthcare settings. Current international recommendations do not support any specific therapies; however, there are a number of agents, which were used during the SARS epidemic of 2003. It is possible that these might be active against the related MERS coronavirus. We have reviewed the literature on the safety and efficacy of therapies used in patients with SARS with a view to their potential use in patients with MERS-CoV infections. International Society for Infectious Diseases. Published by Elsevier Ltd. 2013-10 2013-08-29 /pmc/articles/PMC7110699/ /pubmed/23993766 http://dx.doi.org/10.1016/j.ijid.2013.07.002 Text en Copyright © 2013 International Society for Infectious Diseases. Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Momattin, Hisham
Mohammed, Khurram
Zumla, Alimuddin
Memish, Ziad A.
Al-Tawfiq, Jaffar A.
Therapeutic Options for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) – possible lessons from a systematic review of SARS-CoV therapy
title Therapeutic Options for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) – possible lessons from a systematic review of SARS-CoV therapy
title_full Therapeutic Options for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) – possible lessons from a systematic review of SARS-CoV therapy
title_fullStr Therapeutic Options for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) – possible lessons from a systematic review of SARS-CoV therapy
title_full_unstemmed Therapeutic Options for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) – possible lessons from a systematic review of SARS-CoV therapy
title_short Therapeutic Options for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) – possible lessons from a systematic review of SARS-CoV therapy
title_sort therapeutic options for middle east respiratory syndrome coronavirus (mers-cov) – possible lessons from a systematic review of sars-cov therapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110699/
https://www.ncbi.nlm.nih.gov/pubmed/23993766
http://dx.doi.org/10.1016/j.ijid.2013.07.002
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