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Predictors of MERS-CoV infection: A large case control study of patients presenting with ILI at a MERS-CoV referral hospital in Saudi Arabia

BACKGROUND: A case control study to better characterize the clinical features, laboratory, and radiological abnormalities associated with MERS-CoV infection in order to help with early identification of this syndrome from other respiratory infections. METHODS: Eighty patients admitted to a hospital...

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Autores principales: Mohd, Hamzah A., Memish, Ziad A., Alfaraj, Sarah H., McClish, Donna, Altuwaijri, Talal, Alanazi, Marzouqah S., Aloqiel, Saleh A., Alenzi, Ahmed M., Bafaqeeh, Fahad, Mohamed, Amal M., Aldosari, Kamel, Ghazal, Sameeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110705/
https://www.ncbi.nlm.nih.gov/pubmed/27671972
http://dx.doi.org/10.1016/j.tmaid.2016.09.008
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author Mohd, Hamzah A.
Memish, Ziad A.
Alfaraj, Sarah H.
McClish, Donna
Altuwaijri, Talal
Alanazi, Marzouqah S.
Aloqiel, Saleh A.
Alenzi, Ahmed M.
Bafaqeeh, Fahad
Mohamed, Amal M.
Aldosari, Kamel
Ghazal, Sameeh
author_facet Mohd, Hamzah A.
Memish, Ziad A.
Alfaraj, Sarah H.
McClish, Donna
Altuwaijri, Talal
Alanazi, Marzouqah S.
Aloqiel, Saleh A.
Alenzi, Ahmed M.
Bafaqeeh, Fahad
Mohamed, Amal M.
Aldosari, Kamel
Ghazal, Sameeh
author_sort Mohd, Hamzah A.
collection PubMed
description BACKGROUND: A case control study to better characterize the clinical features, laboratory, and radiological abnormalities associated with MERS-CoV infection in order to help with early identification of this syndrome from other respiratory infections. METHODS: Eighty patients admitted to a hospital in Riyadh, diagnosed with MERS-CoV infection based on RT-PCR were matched on age, sex, and the presence of a co-morbid condition on a basis of 1:2 to other patients admitted with respiratory symptoms and tested negative for MERS-CoV on RT-PCR. RESULTS: None of the reported MERS-CoV presenting symptoms was significantly associated with being infected with MERS-CoV. On the other hand, WBC count was significantly lower in patients with confirmed MERS-CoV infection (median 5.7 vs 9.3, P: 0.0004). Neutrophil count was as well significantly lower in MERS-CoV patients (median 3.7 vs 6.7, P: 0.0001). Both AST, and ALT values were significantly higher in MERS-CoV infected group (AST median 42 vs 36, P: 0.03, and ALT median 33 vs 28, P: 0.003). Overall our MERS-CoV mortality rate was (10%) below the national figure of (40%). CONCLUSIONS: None of the presenting symptoms are specific for MERS-CoV infection. And out of all the investigations WBC, neutrophil counts, AST and ALT values have some predictive utility.
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spelling pubmed-71107052020-04-02 Predictors of MERS-CoV infection: A large case control study of patients presenting with ILI at a MERS-CoV referral hospital in Saudi Arabia Mohd, Hamzah A. Memish, Ziad A. Alfaraj, Sarah H. McClish, Donna Altuwaijri, Talal Alanazi, Marzouqah S. Aloqiel, Saleh A. Alenzi, Ahmed M. Bafaqeeh, Fahad Mohamed, Amal M. Aldosari, Kamel Ghazal, Sameeh Travel Med Infect Dis Article BACKGROUND: A case control study to better characterize the clinical features, laboratory, and radiological abnormalities associated with MERS-CoV infection in order to help with early identification of this syndrome from other respiratory infections. METHODS: Eighty patients admitted to a hospital in Riyadh, diagnosed with MERS-CoV infection based on RT-PCR were matched on age, sex, and the presence of a co-morbid condition on a basis of 1:2 to other patients admitted with respiratory symptoms and tested negative for MERS-CoV on RT-PCR. RESULTS: None of the reported MERS-CoV presenting symptoms was significantly associated with being infected with MERS-CoV. On the other hand, WBC count was significantly lower in patients with confirmed MERS-CoV infection (median 5.7 vs 9.3, P: 0.0004). Neutrophil count was as well significantly lower in MERS-CoV patients (median 3.7 vs 6.7, P: 0.0001). Both AST, and ALT values were significantly higher in MERS-CoV infected group (AST median 42 vs 36, P: 0.03, and ALT median 33 vs 28, P: 0.003). Overall our MERS-CoV mortality rate was (10%) below the national figure of (40%). CONCLUSIONS: None of the presenting symptoms are specific for MERS-CoV infection. And out of all the investigations WBC, neutrophil counts, AST and ALT values have some predictive utility. Elsevier Ltd. 2016 2016-09-24 /pmc/articles/PMC7110705/ /pubmed/27671972 http://dx.doi.org/10.1016/j.tmaid.2016.09.008 Text en © 2016 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Mohd, Hamzah A.
Memish, Ziad A.
Alfaraj, Sarah H.
McClish, Donna
Altuwaijri, Talal
Alanazi, Marzouqah S.
Aloqiel, Saleh A.
Alenzi, Ahmed M.
Bafaqeeh, Fahad
Mohamed, Amal M.
Aldosari, Kamel
Ghazal, Sameeh
Predictors of MERS-CoV infection: A large case control study of patients presenting with ILI at a MERS-CoV referral hospital in Saudi Arabia
title Predictors of MERS-CoV infection: A large case control study of patients presenting with ILI at a MERS-CoV referral hospital in Saudi Arabia
title_full Predictors of MERS-CoV infection: A large case control study of patients presenting with ILI at a MERS-CoV referral hospital in Saudi Arabia
title_fullStr Predictors of MERS-CoV infection: A large case control study of patients presenting with ILI at a MERS-CoV referral hospital in Saudi Arabia
title_full_unstemmed Predictors of MERS-CoV infection: A large case control study of patients presenting with ILI at a MERS-CoV referral hospital in Saudi Arabia
title_short Predictors of MERS-CoV infection: A large case control study of patients presenting with ILI at a MERS-CoV referral hospital in Saudi Arabia
title_sort predictors of mers-cov infection: a large case control study of patients presenting with ili at a mers-cov referral hospital in saudi arabia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110705/
https://www.ncbi.nlm.nih.gov/pubmed/27671972
http://dx.doi.org/10.1016/j.tmaid.2016.09.008
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