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The usefulness of C-reactive protein as a biomarker in predicting neonatal sepsis in a sub-Saharan African region

OBJECTIVE: The early diagnosis of neonatal sepsis remains a challenge for physicians. The initiation or/and discontinuation of the empirical antibiotic therapy at neonates with sepsis is a dilemma due to the lack of definitive diagnosis and the fear of misdiagnosing a case with its serious outcomes,...

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Autores principales: Bunduki, Gabriel Kambale, Adu-Sarkodie, Yaw
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110732/
https://www.ncbi.nlm.nih.gov/pubmed/32238170
http://dx.doi.org/10.1186/s13104-020-05033-1
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author Bunduki, Gabriel Kambale
Adu-Sarkodie, Yaw
author_facet Bunduki, Gabriel Kambale
Adu-Sarkodie, Yaw
author_sort Bunduki, Gabriel Kambale
collection PubMed
description OBJECTIVE: The early diagnosis of neonatal sepsis remains a challenge for physicians. The initiation or/and discontinuation of the empirical antibiotic therapy at neonates with sepsis is a dilemma due to the lack of definitive diagnosis and the fear of misdiagnosing a case with its serious outcomes, which can follow up. Therefore, this study aimed to assess the usefulness of C-reactive protein (CRP) as an inflammatory biomarker in the prediction of the neonatal sepsis diagnosis in Butembo, the Democratic Republic of the Congo, in sub-Saharan Africa. Blood culture and quantitative CRP measurements were performed for each neonate. Receiver operating characteristics (ROC) analyses were done in the assessment of CRP accuracy in diagnosing neonatal sepsis. RESULTS: Of the 228 neonates screened for sepsis, 69 (30.3%) had a positive blood culture. Of the 228 neonates with suspected sepsis, 94 (41.2%) had a positive CRP. Among the 69 cases with positive blood culture, CRP identified 66 cases. The sensitivity, specificity, positive and negative predictive values of CRP were 95.7%, 82.4%, 70.2%, and 97.8%, respectively. The area under the curve (AUC) for the CRP ROC analysis was 0.948. CRP showed its usefulness in the diagnosis of neonatal sepsis.
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spelling pubmed-71107322020-04-07 The usefulness of C-reactive protein as a biomarker in predicting neonatal sepsis in a sub-Saharan African region Bunduki, Gabriel Kambale Adu-Sarkodie, Yaw BMC Res Notes Research Note OBJECTIVE: The early diagnosis of neonatal sepsis remains a challenge for physicians. The initiation or/and discontinuation of the empirical antibiotic therapy at neonates with sepsis is a dilemma due to the lack of definitive diagnosis and the fear of misdiagnosing a case with its serious outcomes, which can follow up. Therefore, this study aimed to assess the usefulness of C-reactive protein (CRP) as an inflammatory biomarker in the prediction of the neonatal sepsis diagnosis in Butembo, the Democratic Republic of the Congo, in sub-Saharan Africa. Blood culture and quantitative CRP measurements were performed for each neonate. Receiver operating characteristics (ROC) analyses were done in the assessment of CRP accuracy in diagnosing neonatal sepsis. RESULTS: Of the 228 neonates screened for sepsis, 69 (30.3%) had a positive blood culture. Of the 228 neonates with suspected sepsis, 94 (41.2%) had a positive CRP. Among the 69 cases with positive blood culture, CRP identified 66 cases. The sensitivity, specificity, positive and negative predictive values of CRP were 95.7%, 82.4%, 70.2%, and 97.8%, respectively. The area under the curve (AUC) for the CRP ROC analysis was 0.948. CRP showed its usefulness in the diagnosis of neonatal sepsis. BioMed Central 2020-04-01 /pmc/articles/PMC7110732/ /pubmed/32238170 http://dx.doi.org/10.1186/s13104-020-05033-1 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Note
Bunduki, Gabriel Kambale
Adu-Sarkodie, Yaw
The usefulness of C-reactive protein as a biomarker in predicting neonatal sepsis in a sub-Saharan African region
title The usefulness of C-reactive protein as a biomarker in predicting neonatal sepsis in a sub-Saharan African region
title_full The usefulness of C-reactive protein as a biomarker in predicting neonatal sepsis in a sub-Saharan African region
title_fullStr The usefulness of C-reactive protein as a biomarker in predicting neonatal sepsis in a sub-Saharan African region
title_full_unstemmed The usefulness of C-reactive protein as a biomarker in predicting neonatal sepsis in a sub-Saharan African region
title_short The usefulness of C-reactive protein as a biomarker in predicting neonatal sepsis in a sub-Saharan African region
title_sort usefulness of c-reactive protein as a biomarker in predicting neonatal sepsis in a sub-saharan african region
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110732/
https://www.ncbi.nlm.nih.gov/pubmed/32238170
http://dx.doi.org/10.1186/s13104-020-05033-1
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