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Cough and viruses in airways disease: Mechanisms
Acute cough is a major symptom of viral respiratory tract infection and causes excessive morbidity in human populations across the world. A wide variety of viruses play a role in the development of cough after acute infection and all of these manifest a similar clinical picture across different age...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Ltd.
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110775/ https://www.ncbi.nlm.nih.gov/pubmed/19480062 http://dx.doi.org/10.1016/j.pupt.2008.12.022 |
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author | Footitt, Joseph Johnston, Sebastian L. |
author_facet | Footitt, Joseph Johnston, Sebastian L. |
author_sort | Footitt, Joseph |
collection | PubMed |
description | Acute cough is a major symptom of viral respiratory tract infection and causes excessive morbidity in human populations across the world. A wide variety of viruses play a role in the development of cough after acute infection and all of these manifest a similar clinical picture across different age groups. Despite the large disease burden surprisingly little is known about the mechanism of acute cough following viral infection. Both in vitro and in vivo experiments show that increased production of neuropeptides and leukotrienes mediate cough after viral infection, along with altered expression of neural receptors. Increased airway mucus production is also likely to play a significant role. This work is reviewed in this article. Following the recent development of a mouse model for rhinovirus infection and the establishment of experimental models of rhinovirus challenge in human subjects with both asthma and COPD the field is expanding to translate in vitro research into clinical studies and hopefully eventually into clinical practice. Developing a clearer understanding of the mechanisms underlying virus induced cough may lead to more specific and effective therapies. |
format | Online Article Text |
id | pubmed-7110775 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71107752020-04-02 Cough and viruses in airways disease: Mechanisms Footitt, Joseph Johnston, Sebastian L. Pulm Pharmacol Ther Article Acute cough is a major symptom of viral respiratory tract infection and causes excessive morbidity in human populations across the world. A wide variety of viruses play a role in the development of cough after acute infection and all of these manifest a similar clinical picture across different age groups. Despite the large disease burden surprisingly little is known about the mechanism of acute cough following viral infection. Both in vitro and in vivo experiments show that increased production of neuropeptides and leukotrienes mediate cough after viral infection, along with altered expression of neural receptors. Increased airway mucus production is also likely to play a significant role. This work is reviewed in this article. Following the recent development of a mouse model for rhinovirus infection and the establishment of experimental models of rhinovirus challenge in human subjects with both asthma and COPD the field is expanding to translate in vitro research into clinical studies and hopefully eventually into clinical practice. Developing a clearer understanding of the mechanisms underlying virus induced cough may lead to more specific and effective therapies. Elsevier Ltd. 2009-04 2009-02-04 /pmc/articles/PMC7110775/ /pubmed/19480062 http://dx.doi.org/10.1016/j.pupt.2008.12.022 Text en Copyright © 2009 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Footitt, Joseph Johnston, Sebastian L. Cough and viruses in airways disease: Mechanisms |
title | Cough and viruses in airways disease: Mechanisms |
title_full | Cough and viruses in airways disease: Mechanisms |
title_fullStr | Cough and viruses in airways disease: Mechanisms |
title_full_unstemmed | Cough and viruses in airways disease: Mechanisms |
title_short | Cough and viruses in airways disease: Mechanisms |
title_sort | cough and viruses in airways disease: mechanisms |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110775/ https://www.ncbi.nlm.nih.gov/pubmed/19480062 http://dx.doi.org/10.1016/j.pupt.2008.12.022 |
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