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Cough and viruses in airways disease: Mechanisms

Acute cough is a major symptom of viral respiratory tract infection and causes excessive morbidity in human populations across the world. A wide variety of viruses play a role in the development of cough after acute infection and all of these manifest a similar clinical picture across different age...

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Detalles Bibliográficos
Autores principales: Footitt, Joseph, Johnston, Sebastian L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110775/
https://www.ncbi.nlm.nih.gov/pubmed/19480062
http://dx.doi.org/10.1016/j.pupt.2008.12.022
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author Footitt, Joseph
Johnston, Sebastian L.
author_facet Footitt, Joseph
Johnston, Sebastian L.
author_sort Footitt, Joseph
collection PubMed
description Acute cough is a major symptom of viral respiratory tract infection and causes excessive morbidity in human populations across the world. A wide variety of viruses play a role in the development of cough after acute infection and all of these manifest a similar clinical picture across different age groups. Despite the large disease burden surprisingly little is known about the mechanism of acute cough following viral infection. Both in vitro and in vivo experiments show that increased production of neuropeptides and leukotrienes mediate cough after viral infection, along with altered expression of neural receptors. Increased airway mucus production is also likely to play a significant role. This work is reviewed in this article. Following the recent development of a mouse model for rhinovirus infection and the establishment of experimental models of rhinovirus challenge in human subjects with both asthma and COPD the field is expanding to translate in vitro research into clinical studies and hopefully eventually into clinical practice. Developing a clearer understanding of the mechanisms underlying virus induced cough may lead to more specific and effective therapies.
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spelling pubmed-71107752020-04-02 Cough and viruses in airways disease: Mechanisms Footitt, Joseph Johnston, Sebastian L. Pulm Pharmacol Ther Article Acute cough is a major symptom of viral respiratory tract infection and causes excessive morbidity in human populations across the world. A wide variety of viruses play a role in the development of cough after acute infection and all of these manifest a similar clinical picture across different age groups. Despite the large disease burden surprisingly little is known about the mechanism of acute cough following viral infection. Both in vitro and in vivo experiments show that increased production of neuropeptides and leukotrienes mediate cough after viral infection, along with altered expression of neural receptors. Increased airway mucus production is also likely to play a significant role. This work is reviewed in this article. Following the recent development of a mouse model for rhinovirus infection and the establishment of experimental models of rhinovirus challenge in human subjects with both asthma and COPD the field is expanding to translate in vitro research into clinical studies and hopefully eventually into clinical practice. Developing a clearer understanding of the mechanisms underlying virus induced cough may lead to more specific and effective therapies. Elsevier Ltd. 2009-04 2009-02-04 /pmc/articles/PMC7110775/ /pubmed/19480062 http://dx.doi.org/10.1016/j.pupt.2008.12.022 Text en Copyright © 2009 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Footitt, Joseph
Johnston, Sebastian L.
Cough and viruses in airways disease: Mechanisms
title Cough and viruses in airways disease: Mechanisms
title_full Cough and viruses in airways disease: Mechanisms
title_fullStr Cough and viruses in airways disease: Mechanisms
title_full_unstemmed Cough and viruses in airways disease: Mechanisms
title_short Cough and viruses in airways disease: Mechanisms
title_sort cough and viruses in airways disease: mechanisms
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110775/
https://www.ncbi.nlm.nih.gov/pubmed/19480062
http://dx.doi.org/10.1016/j.pupt.2008.12.022
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