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Successful generation of epigenetic disease model mice by targeted demethylation of the epigenome

BACKGROUND: Epigenetic modifications, including DNA methylation, play an important role in gene silencing and genome stability. Consequently, epigenetic dysregulation can cause several diseases, such as cancer, obesity, diabetes, autism, and imprinting disorders. RESULTS: We validate three methods f...

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Detalles Bibliográficos
Autores principales:	Horii, Takuro, Morita, Sumiyo, Hino, Shinjiro, Kimura, Mika, Hino, Yuko, Kogo, Hiroshi, Nakao, Mitsuyoshi, Hatada, Izuho
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110793/ https://www.ncbi.nlm.nih.gov/pubmed/32234052 http://dx.doi.org/10.1186/s13059-020-01991-8

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