Stereotactically Injected Kv1.2 and CASPR2 Antisera Cause Differential Effects on CA1 Synaptic and Cellular Excitability, but Both Enhance the Vulnerability to Pro-epileptic Conditions

PURPOSE: We present a case of voltage-gated potassium channel (VGKC) complex antibody-positive limbic encephalitis (LE) harboring autoantibodies against Kv1.2. Since the patient responded well to immunotherapy, the autoantibodies were regarded as pathogenic. We aimed to characterize the pathophysiol...

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Detalles Bibliográficos
Autores principales: Kirschstein, Timo, Sadkiewicz, Erika, Hund-Göschel, Gerda, Becker, Juliane, Guli, Xiati, Müller, Steffen, Rohde, Marco, Hübner, Dora-Charlotte, Brehme, Hannes, Kolbaske, Stephan, Porath, Katrin, Sellmann, Tina, Großmann, Annette, Wittstock, Matthias, Syrbe, Steffen, Storch, Alexander, Köhling, Rüdiger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110982/
https://www.ncbi.nlm.nih.gov/pubmed/32269520
http://dx.doi.org/10.3389/fnsyn.2020.00013

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