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Sometimes Intermediates Do the Job!
The SARS coronavirus main proteinase is a prime target for antiviral therapy. In this issue of Chemistry & Biology, Wu et al. describe potent inhibition of the enzyme by benzotriazole esters, which were originally obtained as intermediates in the synthesis of lopinavir derivatives [1].
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Ltd.
2006
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111035/ https://www.ncbi.nlm.nih.gov/pubmed/16638527 http://dx.doi.org/10.1016/j.chembiol.2006.03.002 |
| _version_ | 1783513190222528512 |
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| author | Hilgenfeld, Rolf Pumpor, Ksenia |
| author_facet | Hilgenfeld, Rolf Pumpor, Ksenia |
| author_sort | Hilgenfeld, Rolf |
| collection | PubMed |
| description | The SARS coronavirus main proteinase is a prime target for antiviral therapy. In this issue of Chemistry & Biology, Wu et al. describe potent inhibition of the enzyme by benzotriazole esters, which were originally obtained as intermediates in the synthesis of lopinavir derivatives [1]. |
| format | Online Article Text |
| id | pubmed-7111035 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2006 |
| publisher | Elsevier Ltd. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-71110352020-04-02 Sometimes Intermediates Do the Job! Hilgenfeld, Rolf Pumpor, Ksenia Chem Biol Article The SARS coronavirus main proteinase is a prime target for antiviral therapy. In this issue of Chemistry & Biology, Wu et al. describe potent inhibition of the enzyme by benzotriazole esters, which were originally obtained as intermediates in the synthesis of lopinavir derivatives [1]. Elsevier Ltd. 2006-03 2006-04-07 /pmc/articles/PMC7111035/ /pubmed/16638527 http://dx.doi.org/10.1016/j.chembiol.2006.03.002 Text en Copyright © 2006 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
| spellingShingle | Article Hilgenfeld, Rolf Pumpor, Ksenia Sometimes Intermediates Do the Job! |
| title | Sometimes Intermediates Do the Job! |
| title_full | Sometimes Intermediates Do the Job! |
| title_fullStr | Sometimes Intermediates Do the Job! |
| title_full_unstemmed | Sometimes Intermediates Do the Job! |
| title_short | Sometimes Intermediates Do the Job! |
| title_sort | sometimes intermediates do the job! |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111035/ https://www.ncbi.nlm.nih.gov/pubmed/16638527 http://dx.doi.org/10.1016/j.chembiol.2006.03.002 |
| work_keys_str_mv | AT hilgenfeldrolf sometimesintermediatesdothejob AT pumporksenia sometimesintermediatesdothejob |