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Ultrasound‐mediated therapies for the treatment of biofilms in chronic wounds: a review of present knowledge
Bacterial biofilms are an ever‐growing concern for public health, featuring both inherited genetic resistance and a conferred innate tolerance to traditional antibiotic therapies. Consequently, there is a growing interest in novel methods of drug delivery, in order to increase the efficacy of antimi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111087/ https://www.ncbi.nlm.nih.gov/pubmed/32237219 http://dx.doi.org/10.1111/1751-7915.13471 |
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author | LuTheryn, Gareth Glynne‐Jones, Peter Webb, Jeremy S Carugo, Dario |
author_facet | LuTheryn, Gareth Glynne‐Jones, Peter Webb, Jeremy S Carugo, Dario |
author_sort | LuTheryn, Gareth |
collection | PubMed |
description | Bacterial biofilms are an ever‐growing concern for public health, featuring both inherited genetic resistance and a conferred innate tolerance to traditional antibiotic therapies. Consequently, there is a growing interest in novel methods of drug delivery, in order to increase the efficacy of antimicrobial agents. One such method is the use of acoustically activated microbubbles, which undergo volumetric oscillations and collapse upon exposure to an ultrasound field. This facilitates physical perturbation of the biofilm and provides the means to control drug delivery both temporally and spatially. In line with current literature in this area, this review offers a rounded argument for why ultrasound‐responsive agents could be an integral part of advancing wound care. To achieve this, we will outline the development and clinical significance of biofilms in the context of chronic infections. We will then discuss current practices used in combating biofilms in chronic wounds and then critically evaluate the use of acoustically activated gas microbubbles as an emerging treatment modality. Moreover, we will introduce the novel concept of microbubbles carrying biologically active gases that may facilitate biofilm dispersal. |
format | Online Article Text |
id | pubmed-7111087 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71110872020-04-02 Ultrasound‐mediated therapies for the treatment of biofilms in chronic wounds: a review of present knowledge LuTheryn, Gareth Glynne‐Jones, Peter Webb, Jeremy S Carugo, Dario Microb Biotechnol Minireviews Bacterial biofilms are an ever‐growing concern for public health, featuring both inherited genetic resistance and a conferred innate tolerance to traditional antibiotic therapies. Consequently, there is a growing interest in novel methods of drug delivery, in order to increase the efficacy of antimicrobial agents. One such method is the use of acoustically activated microbubbles, which undergo volumetric oscillations and collapse upon exposure to an ultrasound field. This facilitates physical perturbation of the biofilm and provides the means to control drug delivery both temporally and spatially. In line with current literature in this area, this review offers a rounded argument for why ultrasound‐responsive agents could be an integral part of advancing wound care. To achieve this, we will outline the development and clinical significance of biofilms in the context of chronic infections. We will then discuss current practices used in combating biofilms in chronic wounds and then critically evaluate the use of acoustically activated gas microbubbles as an emerging treatment modality. Moreover, we will introduce the novel concept of microbubbles carrying biologically active gases that may facilitate biofilm dispersal. John Wiley and Sons Inc. 2019-08-07 /pmc/articles/PMC7111087/ /pubmed/32237219 http://dx.doi.org/10.1111/1751-7915.13471 Text en © 2019 The Authors. Microbial Biotechnology published by John Wiley & Sons Ltd and Society for Applied Microbiology. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Minireviews LuTheryn, Gareth Glynne‐Jones, Peter Webb, Jeremy S Carugo, Dario Ultrasound‐mediated therapies for the treatment of biofilms in chronic wounds: a review of present knowledge |
title | Ultrasound‐mediated therapies for the treatment of biofilms in chronic wounds: a review of present knowledge |
title_full | Ultrasound‐mediated therapies for the treatment of biofilms in chronic wounds: a review of present knowledge |
title_fullStr | Ultrasound‐mediated therapies for the treatment of biofilms in chronic wounds: a review of present knowledge |
title_full_unstemmed | Ultrasound‐mediated therapies for the treatment of biofilms in chronic wounds: a review of present knowledge |
title_short | Ultrasound‐mediated therapies for the treatment of biofilms in chronic wounds: a review of present knowledge |
title_sort | ultrasound‐mediated therapies for the treatment of biofilms in chronic wounds: a review of present knowledge |
topic | Minireviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111087/ https://www.ncbi.nlm.nih.gov/pubmed/32237219 http://dx.doi.org/10.1111/1751-7915.13471 |
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