Selective Inhibition of USP7

The deubiquitinating enzyme USP7 is an emerging oncology and antiviral target. Reverdy et al., in this issue of Chemistry & Biology, disclose the first small-molecule inhibitor selective for USP7, which recapitulates its knockdown in cancer cells and hence demonstrates the therapeutic feasibilit...

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Detalles Bibliográficos
Autores principales: Menard, Robert, Sulea, Traian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2012
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111172/
https://www.ncbi.nlm.nih.gov/pubmed/22520747
http://dx.doi.org/10.1016/j.chembiol.2012.04.001
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author Menard, Robert
Sulea, Traian
author_facet Menard, Robert
Sulea, Traian
author_sort Menard, Robert
collection PubMed
description The deubiquitinating enzyme USP7 is an emerging oncology and antiviral target. Reverdy et al., in this issue of Chemistry & Biology, disclose the first small-molecule inhibitor selective for USP7, which recapitulates its knockdown in cancer cells and hence demonstrates the therapeutic feasibility of USP7 inhibitors.
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spelling pubmed-71111722020-04-02 Selective Inhibition of USP7 Menard, Robert Sulea, Traian Chem Biol Preview The deubiquitinating enzyme USP7 is an emerging oncology and antiviral target. Reverdy et al., in this issue of Chemistry & Biology, disclose the first small-molecule inhibitor selective for USP7, which recapitulates its knockdown in cancer cells and hence demonstrates the therapeutic feasibility of USP7 inhibitors. Elsevier Ltd. 2012-04-20 2012-04-19 /pmc/articles/PMC7111172/ /pubmed/22520747 http://dx.doi.org/10.1016/j.chembiol.2012.04.001 Text en Copyright © 2012 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Preview
Menard, Robert
Sulea, Traian
Selective Inhibition of USP7
title Selective Inhibition of USP7
title_full Selective Inhibition of USP7
title_fullStr Selective Inhibition of USP7
title_full_unstemmed Selective Inhibition of USP7
title_short Selective Inhibition of USP7
title_sort selective inhibition of usp7
topic Preview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111172/
https://www.ncbi.nlm.nih.gov/pubmed/22520747
http://dx.doi.org/10.1016/j.chembiol.2012.04.001
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