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Mucin gene expression in rat airways following infection and irritation

Airway mucus hypersecretion occurs in response to infection and irritation and poses an important and poorly understood clinical problem. In order to gain insight into its pathogenesis, we have focused on an mRNA encoding the major mucus glycoprotein, mucin. Northern blots showed that mucin mRNA was...

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Autores principales: Jany, Berthold, Gallup, Marianne, Tsuda, Tohru, Basbaum, Carol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Inc. 1991
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111198/
https://www.ncbi.nlm.nih.gov/pubmed/1659805
http://dx.doi.org/10.1016/S0006-291X(05)81373-7
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author Jany, Berthold
Gallup, Marianne
Tsuda, Tohru
Basbaum, Carol
author_facet Jany, Berthold
Gallup, Marianne
Tsuda, Tohru
Basbaum, Carol
author_sort Jany, Berthold
collection PubMed
description Airway mucus hypersecretion occurs in response to infection and irritation and poses an important and poorly understood clinical problem. In order to gain insight into its pathogenesis, we have focused on an mRNA encoding the major mucus glycoprotein, mucin. Northern blots showed that mucin mRNA was abundant in the intestine of specific pathogen free rats whereas it was undetectable in the airways of these rats until pathogen-free conditions were suspended and rats acquired Sendai (Parainfluenza I) virus infections. Airway mucin hybridization signals in rats that were both infected with Sendai virus and exposed to SO(2)were more intense than those in rats with infection alone. These results suggest that pathogen-and irritant-induced hypersecretion may be partly controlled at the level of mucin mRNA.
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spelling pubmed-71111982020-04-02 Mucin gene expression in rat airways following infection and irritation Jany, Berthold Gallup, Marianne Tsuda, Tohru Basbaum, Carol Biochem Biophys Res Commun Article Airway mucus hypersecretion occurs in response to infection and irritation and poses an important and poorly understood clinical problem. In order to gain insight into its pathogenesis, we have focused on an mRNA encoding the major mucus glycoprotein, mucin. Northern blots showed that mucin mRNA was abundant in the intestine of specific pathogen free rats whereas it was undetectable in the airways of these rats until pathogen-free conditions were suspended and rats acquired Sendai (Parainfluenza I) virus infections. Airway mucin hybridization signals in rats that were both infected with Sendai virus and exposed to SO(2)were more intense than those in rats with infection alone. These results suggest that pathogen-and irritant-induced hypersecretion may be partly controlled at the level of mucin mRNA. Published by Elsevier Inc. 1991-11-27 2005-04-04 /pmc/articles/PMC7111198/ /pubmed/1659805 http://dx.doi.org/10.1016/S0006-291X(05)81373-7 Text en Copyright © 1991 Published by Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Jany, Berthold
Gallup, Marianne
Tsuda, Tohru
Basbaum, Carol
Mucin gene expression in rat airways following infection and irritation
title Mucin gene expression in rat airways following infection and irritation
title_full Mucin gene expression in rat airways following infection and irritation
title_fullStr Mucin gene expression in rat airways following infection and irritation
title_full_unstemmed Mucin gene expression in rat airways following infection and irritation
title_short Mucin gene expression in rat airways following infection and irritation
title_sort mucin gene expression in rat airways following infection and irritation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111198/
https://www.ncbi.nlm.nih.gov/pubmed/1659805
http://dx.doi.org/10.1016/S0006-291X(05)81373-7
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