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Mucin gene expression in rat airways following infection and irritation
Airway mucus hypersecretion occurs in response to infection and irritation and poses an important and poorly understood clinical problem. In order to gain insight into its pathogenesis, we have focused on an mRNA encoding the major mucus glycoprotein, mucin. Northern blots showed that mucin mRNA was...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Published by Elsevier Inc.
1991
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111198/ https://www.ncbi.nlm.nih.gov/pubmed/1659805 http://dx.doi.org/10.1016/S0006-291X(05)81373-7 |
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author | Jany, Berthold Gallup, Marianne Tsuda, Tohru Basbaum, Carol |
author_facet | Jany, Berthold Gallup, Marianne Tsuda, Tohru Basbaum, Carol |
author_sort | Jany, Berthold |
collection | PubMed |
description | Airway mucus hypersecretion occurs in response to infection and irritation and poses an important and poorly understood clinical problem. In order to gain insight into its pathogenesis, we have focused on an mRNA encoding the major mucus glycoprotein, mucin. Northern blots showed that mucin mRNA was abundant in the intestine of specific pathogen free rats whereas it was undetectable in the airways of these rats until pathogen-free conditions were suspended and rats acquired Sendai (Parainfluenza I) virus infections. Airway mucin hybridization signals in rats that were both infected with Sendai virus and exposed to SO(2)were more intense than those in rats with infection alone. These results suggest that pathogen-and irritant-induced hypersecretion may be partly controlled at the level of mucin mRNA. |
format | Online Article Text |
id | pubmed-7111198 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1991 |
publisher | Published by Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71111982020-04-02 Mucin gene expression in rat airways following infection and irritation Jany, Berthold Gallup, Marianne Tsuda, Tohru Basbaum, Carol Biochem Biophys Res Commun Article Airway mucus hypersecretion occurs in response to infection and irritation and poses an important and poorly understood clinical problem. In order to gain insight into its pathogenesis, we have focused on an mRNA encoding the major mucus glycoprotein, mucin. Northern blots showed that mucin mRNA was abundant in the intestine of specific pathogen free rats whereas it was undetectable in the airways of these rats until pathogen-free conditions were suspended and rats acquired Sendai (Parainfluenza I) virus infections. Airway mucin hybridization signals in rats that were both infected with Sendai virus and exposed to SO(2)were more intense than those in rats with infection alone. These results suggest that pathogen-and irritant-induced hypersecretion may be partly controlled at the level of mucin mRNA. Published by Elsevier Inc. 1991-11-27 2005-04-04 /pmc/articles/PMC7111198/ /pubmed/1659805 http://dx.doi.org/10.1016/S0006-291X(05)81373-7 Text en Copyright © 1991 Published by Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Jany, Berthold Gallup, Marianne Tsuda, Tohru Basbaum, Carol Mucin gene expression in rat airways following infection and irritation |
title | Mucin gene expression in rat airways following infection and irritation |
title_full | Mucin gene expression in rat airways following infection and irritation |
title_fullStr | Mucin gene expression in rat airways following infection and irritation |
title_full_unstemmed | Mucin gene expression in rat airways following infection and irritation |
title_short | Mucin gene expression in rat airways following infection and irritation |
title_sort | mucin gene expression in rat airways following infection and irritation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111198/ https://www.ncbi.nlm.nih.gov/pubmed/1659805 http://dx.doi.org/10.1016/S0006-291X(05)81373-7 |
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