Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization

Structural principles underlying the composition of protective antiviral monoclonal antibody (mAb) cocktails are poorly defined. Here, we exploited antibody cooperativity to develop a therapeutic mAb cocktail against Ebola virus. We systematically analyzed the antibody repertoire in human survivors...

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Detalles Bibliográficos
Autores principales: Gilchuk, Pavlo, Murin, Charles D., Milligan, Jacob C., Cross, Robert W., Mire, Chad E., Ilinykh, Philipp A., Huang, Kai, Kuzmina, Natalia, Altman, Pilar X., Hui, Sean, Gunn, Bronwyn M., Bryan, Aubrey L., Davidson, Edgar, Doranz, Benjamin J., Turner, Hannah L., Alkutkar, Tanwee, Flinko, Robin, Orlandi, Chiara, Carnahan, Robert, Nargi, Rachel, Bombardi, Robin G., Vodzak, Megan E., Li, Sheng, Okoli, Adaora, Ibeawuchi, Morris, Ohiaeri, Benjamin, Lewis, George K., Alter, Galit, Bukreyev, Alexander, Saphire, Erica Ollmann, Geisbert, Thomas W., Ward, Andrew B., Crowe, James E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111202/
https://www.ncbi.nlm.nih.gov/pubmed/32023489
http://dx.doi.org/10.1016/j.immuni.2020.01.001

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