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Broad-spectrum antiviral activity of carbodine, the carbocyclic analogue of cytidine
Carbocyclic cytidine (C-Cyd) is a broad-spectrum antiviral agent active against DNA viruses [pox (vaccinia)], (+)RNA viruses [toga (Sindbis, Semliki forest), corona], (−)RNA viruses [orthomyxo (influenza), paramyxo (parainfluenza, measles), rhabdo (vesicular stomatitis)] and (±)RNA viruses (reo). Th...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Published by Elsevier Inc.
1990
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111205/ https://www.ncbi.nlm.nih.gov/pubmed/1689159 http://dx.doi.org/10.1016/0006-2952(90)90031-F |
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author | De Clercq, Erik Bernaerts, Ria Shealy, Y.Fulmer Montgomery, John A. |
author_facet | De Clercq, Erik Bernaerts, Ria Shealy, Y.Fulmer Montgomery, John A. |
author_sort | De Clercq, Erik |
collection | PubMed |
description | Carbocyclic cytidine (C-Cyd) is a broad-spectrum antiviral agent active against DNA viruses [pox (vaccinia)], (+)RNA viruses [toga (Sindbis, Semliki forest), corona], (−)RNA viruses [orthomyxo (influenza), paramyxo (parainfluenza, measles), rhabdo (vesicular stomatitis)] and (±)RNA viruses (reo). The target enzyme of C-Cyd is supposed to be CTP synthetase that converts UTP to CTP. In keeping with this assumption are the observations that (i) C-Cyd effects a dose-dependent inhibition of RNA synthesis in both virus-infected and uninfected cells, and (ii) exogenous addition of either Urd or Cyd reverses both the antiviral and cytocidal activity of C-Cyd, whereas addition of dThd or dCyd fails to do so. The selectivity of C-Cyd against Sindbis, vesicular stomatitis and reo virus is markedly increased when C-Cyd is combined with Cyd (10 μg/mL). This combination may therefore be worth pursuing as a chemotherapeutic modality for the treatment of virus infections. |
format | Online Article Text |
id | pubmed-7111205 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1990 |
publisher | Published by Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71112052020-04-02 Broad-spectrum antiviral activity of carbodine, the carbocyclic analogue of cytidine De Clercq, Erik Bernaerts, Ria Shealy, Y.Fulmer Montgomery, John A. Biochem Pharmacol Article Carbocyclic cytidine (C-Cyd) is a broad-spectrum antiviral agent active against DNA viruses [pox (vaccinia)], (+)RNA viruses [toga (Sindbis, Semliki forest), corona], (−)RNA viruses [orthomyxo (influenza), paramyxo (parainfluenza, measles), rhabdo (vesicular stomatitis)] and (±)RNA viruses (reo). The target enzyme of C-Cyd is supposed to be CTP synthetase that converts UTP to CTP. In keeping with this assumption are the observations that (i) C-Cyd effects a dose-dependent inhibition of RNA synthesis in both virus-infected and uninfected cells, and (ii) exogenous addition of either Urd or Cyd reverses both the antiviral and cytocidal activity of C-Cyd, whereas addition of dThd or dCyd fails to do so. The selectivity of C-Cyd against Sindbis, vesicular stomatitis and reo virus is markedly increased when C-Cyd is combined with Cyd (10 μg/mL). This combination may therefore be worth pursuing as a chemotherapeutic modality for the treatment of virus infections. Published by Elsevier Inc. 1990-01-15 2002-11-08 /pmc/articles/PMC7111205/ /pubmed/1689159 http://dx.doi.org/10.1016/0006-2952(90)90031-F Text en Copyright © 1989 Published by Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article De Clercq, Erik Bernaerts, Ria Shealy, Y.Fulmer Montgomery, John A. Broad-spectrum antiviral activity of carbodine, the carbocyclic analogue of cytidine |
title | Broad-spectrum antiviral activity of carbodine, the carbocyclic analogue of cytidine |
title_full | Broad-spectrum antiviral activity of carbodine, the carbocyclic analogue of cytidine |
title_fullStr | Broad-spectrum antiviral activity of carbodine, the carbocyclic analogue of cytidine |
title_full_unstemmed | Broad-spectrum antiviral activity of carbodine, the carbocyclic analogue of cytidine |
title_short | Broad-spectrum antiviral activity of carbodine, the carbocyclic analogue of cytidine |
title_sort | broad-spectrum antiviral activity of carbodine, the carbocyclic analogue of cytidine |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111205/ https://www.ncbi.nlm.nih.gov/pubmed/1689159 http://dx.doi.org/10.1016/0006-2952(90)90031-F |
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