Systemic HIV and SIV latency reversal via non-canonical NF-κB signalling in vivo

Long-lasting, latently-infected, resting CD4(+) T cells are the greatest obstacle to cure HIV infection, as they persist despite decades of treatment with ART. Estimates indicate the need for >70 years of continuous, fully suppressive, antiretroviral therapy (ART) to eliminate the HIV reservoir(1...

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Detalles Bibliográficos
Autores principales: Nixon, Christopher C., Mavigner, Maud, Sampey, Gavin C., Brooks, Alyssa D., Spagnuolo, Rae Ann, Irlbeck, David M., Mattingly, Cameron, Ho, Phong T., Schoof, Nils, Cammon, Corinne G., Tharp, Greg K., Kanke, Matthew, Wang, Zhang, Cleary, Rachel A., Upadhyay, Amit A., De, Chandrav, Wills, Saintedym R., Falcinelli, Shane D., Galardi, Cristin, Walum, Hasse, Schramm, Nathaniel J., Deutsch, Jennifer, Lifson, Jeffrey D., Fennessey, Christine M., Keele, Brandon F., Jean, Sherrie, Maguire, Sean, Liao, Baolin, Browne, Edward P., Ferris, Robert G., Brehm, Jessica H., Favre, David, Vanderford, Thomas H., Bosinger, Steven E., Jones, Corbin D., Routy, Jean-Pierre, Archin, Nancie M., Margolis, David M., Wahl, Angela, Dunham, Richard M., Silvestri, Guido, Chahroudi, Ann, Garcia, J. Victor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111210/
https://www.ncbi.nlm.nih.gov/pubmed/31969707
http://dx.doi.org/10.1038/s41586-020-1951-3

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