Molecular Evolution of Human Coronavirus Genomes

Human coronaviruses (HCoVs), including SARS-CoV and MERS-CoV, are zoonotic pathogens that originated in wild animals. HCoVs have large genomes that encode a fixed array of structural and nonstructural components, as well as a variety of accessory proteins that differ in number and sequence even amon...

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Detalles Bibliográficos
Autores principales: Forni, Diego, Cagliani, Rachele, Clerici, Mario, Sironi, Manuela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111218/
https://www.ncbi.nlm.nih.gov/pubmed/27743750
http://dx.doi.org/10.1016/j.tim.2016.09.001
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author Forni, Diego
Cagliani, Rachele
Clerici, Mario
Sironi, Manuela
author_facet Forni, Diego
Cagliani, Rachele
Clerici, Mario
Sironi, Manuela
author_sort Forni, Diego
collection PubMed
description Human coronaviruses (HCoVs), including SARS-CoV and MERS-CoV, are zoonotic pathogens that originated in wild animals. HCoVs have large genomes that encode a fixed array of structural and nonstructural components, as well as a variety of accessory proteins that differ in number and sequence even among closely related CoVs. Thus, in addition to recombination and mutation, HCoV genomes evolve through gene gains and losses. In this review we summarize recent findings on the molecular evolution of HCoV genomes, with special attention to recombination and adaptive events that generated new viral species and contributed to host shifts and to HCoV emergence. VIDEO ABSTRACT:
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spelling pubmed-71112182020-04-02 Molecular Evolution of Human Coronavirus Genomes Forni, Diego Cagliani, Rachele Clerici, Mario Sironi, Manuela Trends Microbiol Review Human coronaviruses (HCoVs), including SARS-CoV and MERS-CoV, are zoonotic pathogens that originated in wild animals. HCoVs have large genomes that encode a fixed array of structural and nonstructural components, as well as a variety of accessory proteins that differ in number and sequence even among closely related CoVs. Thus, in addition to recombination and mutation, HCoV genomes evolve through gene gains and losses. In this review we summarize recent findings on the molecular evolution of HCoV genomes, with special attention to recombination and adaptive events that generated new viral species and contributed to host shifts and to HCoV emergence. VIDEO ABSTRACT: Elsevier Ltd. 2017-01 2016-10-19 /pmc/articles/PMC7111218/ /pubmed/27743750 http://dx.doi.org/10.1016/j.tim.2016.09.001 Text en © 2016 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Forni, Diego
Cagliani, Rachele
Clerici, Mario
Sironi, Manuela
Molecular Evolution of Human Coronavirus Genomes
title Molecular Evolution of Human Coronavirus Genomes
title_full Molecular Evolution of Human Coronavirus Genomes
title_fullStr Molecular Evolution of Human Coronavirus Genomes
title_full_unstemmed Molecular Evolution of Human Coronavirus Genomes
title_short Molecular Evolution of Human Coronavirus Genomes
title_sort molecular evolution of human coronavirus genomes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111218/
https://www.ncbi.nlm.nih.gov/pubmed/27743750
http://dx.doi.org/10.1016/j.tim.2016.09.001
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