Phytomolecule icaritin incorporated PLGA/TCP scaffold for steroid-associated osteonecrosis: Proof-of-concept for prevention of hip joint collapse in bipedal emus and mechanistic study in quadrupedal rabbits

Steroid-associated osteonecrosis (SAON) may lead to joint collapse and subsequent joint replacement. Poly lactic-co-glycolic acid/tricalcium phosphate (P/T) scaffold providing sustained release of icaritin (a metabolite of Epimedium-derived flavonoids) was investigated as a bone defect filler after...

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Detalles Bibliográficos
Autores principales: Qin, Ling, Yao, Dong, Zheng, Lizhen, Liu, Wai-Ching, Liu, Zhong, Lei, Ming, Huang, Le, Xie, Xinhui, Wang, Xinluan, Chen, Yang, Yao, Xinsheng, Peng, Jiang, Gong, He, Griffith, James F., Huang, Yanping, Zheng, Yongping, Feng, Jian Q., Liu, Ying, Chen, Shihui, Xiao, Deming, Wang, Daping, Xiong, Jiangyi, Pei, Duanqing, Zhang, Peng, Pan, Xiaohua, Wang, Xiaohong, Lee, Kwong-Man, Cheng, Chun-Yiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111223/
https://www.ncbi.nlm.nih.gov/pubmed/25968462
http://dx.doi.org/10.1016/j.biomaterials.2015.04.038

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