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Pharmaceutical and medicinal significance of sulfur (S(VI))-Containing motifs for drug discovery: A critical review

Sulfur (S(VI)) based moieties, especially, the sulfonyl or sulfonamide based analogues have showed a variety of pharmacological properties, and its derivatives propose a high degree of structural diversity that has established useful for the finding of new therapeutic agents. The developments of new...

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Detalles Bibliográficos
Autores principales: Zhao, Chuang, Rakesh, K.P., Ravidar, L., Fang, Wan-Yin, Qin, Hua-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Masson SAS. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111228/
https://www.ncbi.nlm.nih.gov/pubmed/30496988
http://dx.doi.org/10.1016/j.ejmech.2018.11.017
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author Zhao, Chuang
Rakesh, K.P.
Ravidar, L.
Fang, Wan-Yin
Qin, Hua-Li
author_facet Zhao, Chuang
Rakesh, K.P.
Ravidar, L.
Fang, Wan-Yin
Qin, Hua-Li
author_sort Zhao, Chuang
collection PubMed
description Sulfur (S(VI)) based moieties, especially, the sulfonyl or sulfonamide based analogues have showed a variety of pharmacological properties, and its derivatives propose a high degree of structural diversity that has established useful for the finding of new therapeutic agents. The developments of new less toxic, low cost and highly active sulfonamides containing analogues are hot research topics in medicinal chemistry. Currently, more than 150 FDA approved Sulfur (S(VI))-based drugs are available in the market, and they are widely used to treat various types of diseases with therapeutic power. This comprehensive review highlights the recent developments of sulfonyl or sulfonamides based compounds in huge range of therapeutic applications such as antimicrobial, anti-inflammatory, antiviral, anticonvulsant, antitubercular, antidiabetic, antileishmanial, carbonic anhydrase, antimalarial, anticancer and other medicinal agents. We believe that, this review article is useful to inspire new ideas for structural design and developments of less toxic and powerful Sulfur (S(VI)) based drugs against the numerous death-causing diseases.
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spelling pubmed-71112282020-04-02 Pharmaceutical and medicinal significance of sulfur (S(VI))-Containing motifs for drug discovery: A critical review Zhao, Chuang Rakesh, K.P. Ravidar, L. Fang, Wan-Yin Qin, Hua-Li Eur J Med Chem Review Article Sulfur (S(VI)) based moieties, especially, the sulfonyl or sulfonamide based analogues have showed a variety of pharmacological properties, and its derivatives propose a high degree of structural diversity that has established useful for the finding of new therapeutic agents. The developments of new less toxic, low cost and highly active sulfonamides containing analogues are hot research topics in medicinal chemistry. Currently, more than 150 FDA approved Sulfur (S(VI))-based drugs are available in the market, and they are widely used to treat various types of diseases with therapeutic power. This comprehensive review highlights the recent developments of sulfonyl or sulfonamides based compounds in huge range of therapeutic applications such as antimicrobial, anti-inflammatory, antiviral, anticonvulsant, antitubercular, antidiabetic, antileishmanial, carbonic anhydrase, antimalarial, anticancer and other medicinal agents. We believe that, this review article is useful to inspire new ideas for structural design and developments of less toxic and powerful Sulfur (S(VI)) based drugs against the numerous death-causing diseases. Elsevier Masson SAS. 2019-01-15 2018-11-22 /pmc/articles/PMC7111228/ /pubmed/30496988 http://dx.doi.org/10.1016/j.ejmech.2018.11.017 Text en © 2018 Elsevier Masson SAS. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review Article
Zhao, Chuang
Rakesh, K.P.
Ravidar, L.
Fang, Wan-Yin
Qin, Hua-Li
Pharmaceutical and medicinal significance of sulfur (S(VI))-Containing motifs for drug discovery: A critical review
title Pharmaceutical and medicinal significance of sulfur (S(VI))-Containing motifs for drug discovery: A critical review
title_full Pharmaceutical and medicinal significance of sulfur (S(VI))-Containing motifs for drug discovery: A critical review
title_fullStr Pharmaceutical and medicinal significance of sulfur (S(VI))-Containing motifs for drug discovery: A critical review
title_full_unstemmed Pharmaceutical and medicinal significance of sulfur (S(VI))-Containing motifs for drug discovery: A critical review
title_short Pharmaceutical and medicinal significance of sulfur (S(VI))-Containing motifs for drug discovery: A critical review
title_sort pharmaceutical and medicinal significance of sulfur (s(vi))-containing motifs for drug discovery: a critical review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111228/
https://www.ncbi.nlm.nih.gov/pubmed/30496988
http://dx.doi.org/10.1016/j.ejmech.2018.11.017
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