MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodeling

MDM2 and MDMX, negative regulators of the tumor suppressor p53, can work separately and as a heteromeric complex to restrain p53's functions. MDM2 also has pro-oncogenic roles in cells, tissues, and animals that are independent of p53. There is less information available about p53-independent r...

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Detalles Bibliográficos
Autores principales: Venkatesh, Divya, O'Brien, Nicholas A., Zandkarimi, Fereshteh, Tong, David R., Stokes, Michael E., Dunn, Denise E., Kengmana, Everett S., Aron, Allegra T., Klein, Alyssa M., Csuka, Joleen M., Moon, Sung-Hwan, Conrad, Marcus, Chang, Christopher J., Lo, Donald C., D'Alessandro, Angelo, Prives, Carol, Stockwell, Brent R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111265/
https://www.ncbi.nlm.nih.gov/pubmed/32079652
http://dx.doi.org/10.1101/gad.334219.119

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