Blunting senescence boosts liver regeneration

The mammalian liver possesses a unique capacity for regeneration. However, this regenerative potential declines with age due to unknown mechanisms. In this issue of Genes & Development, Ritschka and colleagues (pp. 489–494). compare liver regeneration upon partial hepatectomy in young and adult...

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Detalles Bibliográficos
Autores principales: Birch, Jodie, Gil, Jesus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Outlook
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111267/
https://www.ncbi.nlm.nih.gov/pubmed/32238449
http://dx.doi.org/10.1101/gad.337394.120
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author Birch, Jodie
Gil, Jesus
author_facet Birch, Jodie
Gil, Jesus
author_sort Birch, Jodie
collection PubMed
description The mammalian liver possesses a unique capacity for regeneration. However, this regenerative potential declines with age due to unknown mechanisms. In this issue of Genes & Development, Ritschka and colleagues (pp. 489–494). compare liver regeneration upon partial hepatectomy in young and adult mice. Partial hepatectomy causes a transient increase in p21 in a subpopulation of hepatocytes that persists in adult mice. Remarkably, treatment with the BCL-2 family inhibitor ABT-737 blunts p21 expression, enhancing liver regeneration.
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spelling pubmed-71112672020-10-01 Blunting senescence boosts liver regeneration Birch, Jodie Gil, Jesus Genes Dev Outlook The mammalian liver possesses a unique capacity for regeneration. However, this regenerative potential declines with age due to unknown mechanisms. In this issue of Genes & Development, Ritschka and colleagues (pp. 489–494). compare liver regeneration upon partial hepatectomy in young and adult mice. Partial hepatectomy causes a transient increase in p21 in a subpopulation of hepatocytes that persists in adult mice. Remarkably, treatment with the BCL-2 family inhibitor ABT-737 blunts p21 expression, enhancing liver regeneration. Cold Spring Harbor Laboratory Press 2020-04-01 /pmc/articles/PMC7111267/ /pubmed/32238449 http://dx.doi.org/10.1101/gad.337394.120 Text en © 2020 Birch and Gil; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Outlook
Birch, Jodie
Gil, Jesus
Blunting senescence boosts liver regeneration
title Blunting senescence boosts liver regeneration
title_full Blunting senescence boosts liver regeneration
title_fullStr Blunting senescence boosts liver regeneration
title_full_unstemmed Blunting senescence boosts liver regeneration
title_short Blunting senescence boosts liver regeneration
title_sort blunting senescence boosts liver regeneration
topic Outlook
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111267/
https://www.ncbi.nlm.nih.gov/pubmed/32238449
http://dx.doi.org/10.1101/gad.337394.120
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