Discovery, synthesis, and optimization of an N-alkoxy indolylacetamide against HIV-1 carrying NNRTI-resistant mutations from the Isatis indigotica root

From an aqueous decoction of the traditional Chinese medicine “ban lan gen” (the Isatis indigotica root), an antiviral natural product CI - 39 was isolated as an NNRTI (non-nucleoside reverse transcriptase inhibitor) (EC(50) = 3.40 μM). Its novel structure was determined as methyl (1-methoxy-1H-indo...

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Detalles Bibliográficos
Autores principales: Xu, Chengbo, Xin, Yijing, Chen, Minghua, Ba, Mingyu, Guo, Qinglan, Zhu, Chenggen, Guo, Ying, Shi, Jiangong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Masson SAS. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111291/
https://www.ncbi.nlm.nih.gov/pubmed/32004936
http://dx.doi.org/10.1016/j.ejmech.2020.112071

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111291/
https://www.ncbi.nlm.nih.gov/pubmed/32004936
http://dx.doi.org/10.1016/j.ejmech.2020.112071

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