Fused-ring structure of decahydroisoquinolin as a novel scaffold for SARS 3CL protease inhibitors

The design and evaluation of a novel decahydroisoquinolin scaffold as an inhibitor for severe acute respiratory syndrome (SARS) chymotrypsin-like protease (3CL(pro)) are described. Focusing on hydrophobic interactions at the S(2) site, the decahydroisoquinolin scaffold was designed by connecting the...

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Detalles Bibliográficos
Autores principales: Shimamoto, Yasuhiro, Hattori, Yasunao, Kobayashi, Kazuya, Teruya, Kenta, Sanjoh, Akira, Nakagawa, Atsushi, Yamashita, Eiki, Akaji, Kenichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111320/
https://www.ncbi.nlm.nih.gov/pubmed/25614110
http://dx.doi.org/10.1016/j.bmc.2014.12.028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111320/
https://www.ncbi.nlm.nih.gov/pubmed/25614110
http://dx.doi.org/10.1016/j.bmc.2014.12.028

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